J
Jun-ichi Hanai
Researcher at Beth Israel Deaconess Medical Center
Publications - 56
Citations - 10141
Jun-ichi Hanai is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: SMAD & Transactivation. The author has an hindex of 35, co-authored 56 publications receiving 9429 citations. Previous affiliations of Jun-ichi Hanai include Harvard University & Japan Society for the Promotion of Science.
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Journal ArticleDOI
Transforming Growth Factor-β1 Inhibition of Vascular Smooth Muscle Cell Activation Is Mediated via Smad3
Mark W. Feinberg,Masafumi Watanabe,Maria A. Lebedeva,Ana S. Depina,Jun-ichi Hanai,Tadanori Mammoto,Joshua P. Frederick,Xiao-Fan Wang,Vikas P. Sukhatme,Mukesh K. Jain +9 more
TL;DR: It is demonstrated here that the ability of TGF-β1 to inhibit markers of VSMC activation, inducible nitric-oxide synthase (iNOS) and interleukin (IL)-6, is mediated through its downstream effector Smad3, which plays an essential role in mediating TGF -β1 anti-inflammatory response in VSMCs.
Journal ArticleDOI
Microarray analysis of in vitro pericyte differentiation reveals an angiogenic program of gene expression.
Sujata Kale,Sujata Kale,Jun-ichi Hanai,Barden Chan,Anil Karihaloo,Gary R. Grotendorst,Lloyd G. Cantley,Vikas P. Sukhatme +7 more
TL;DR: The results of these studies show that factors produced by pericytes may be responsible for recruiting ECs and promoting angiogenesis, and further understanding of the genes involved in pericyte differentiation could provide a novel approach for developing anti‐angiogenic therapies.
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A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro
Guang Hu,Jian Tang,Bo Zhang,Yanfeng Lin,Jun-ichi Hanai,Jenna L. Galloway,Victoria M. Bedell,Nathan Bahary,Zhihua Han,Ramani Ramchandran,Bernard Thisse,Christine Thisse,Leonard I. Zon,Vikas P. Sukhatme +13 more
TL;DR: The data suggests that HspA12B is a highly endothelial-cell-specific distant member of the Hsp70 family and plays a significant role in endothelial cells during development and angiogenesis in vitro, partially attributable to modulation of Akt phosphorylation.
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In vivo evidence for a limited role of proximal tubular Klotho in renal phosphate handling
Noriko Ide,Hannes Olauson,Tadatoshi Sato,Michael J. Densmore,Hao Wang,Jun-ichi Hanai,Tobias E. Larsson,Beate Lanske +7 more
TL;DR: Klotho expressed in the proximal tubules has a defined but limited role in renal phosphate handling in vivo and hyperphosphatemia in knockout mice was mild or nonexistent under basal conditions but occurred upon high phosphate loading, indicating the presence of compensatory mechanisms.
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A Critical Role for Calponin 2 in Vascular Development
Jian Tang,Guang Hu,Jun-ichi Hanai,Ganesh Yadlapalli,Yanfeng Lin,Bo Zhang,Jenna L. Galloway,Nathan Bahary,Sonia Sinha,Bernard Thisse,Christine Thisse,Jian Ping Jin,Leonard I. Zon,Vikas P. Sukhatme +13 more
TL;DR: Data suggest that calponin 2 plays an important role in the migration of endothelial cells both in vivo and in vitro and that its expression is critical for proper vascular development.