Jun-ichi Hanai

TL;DR: Computational modeling indicates a new class of ACL inhibitors bearing the key structural feature of the natural product emodin occupies an allosteric binding site and blocks the entrance of the substrate citrate to its binding site.

TL;DR: New zebrafish models for a human premature aging disorder are generated and the utility for studying laminopathies is demonstrated, which may provide a new platform for future drug screening as well as genetic analyses aimed at identifying modifier genes that influence not only progeria and laminationopathies but also other age-associated human diseases common in vertebrates.

TL;DR: The results suggest that TERT non-canonically functions in hematopoietic cell differentiation and survival in vertebrates, independently of its role in telomere homeostasis.

TL;DR: The recent study demonstrated that Smads exist as monomers in the absence of TGF‐β, and a missense mutation of Smad2 identified in colorectal and lung cancers was introduced to Smad3, which could actively contribute to oncogenesis.

TL;DR: PTH1R signaling directly and indirectly regulates the paracellular Ca2+ transport pathway by modulating Cldn14 expression in the TAL, suggesting that down-regulation of Claudin14 could provide a potential treatment option to correct urinary Ca2- loss, particularly in patients with hypoparathyroidism.