J
Jun-ichi Hanai
Researcher at Beth Israel Deaconess Medical Center
Publications - 56
Citations - 10141
Jun-ichi Hanai is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: SMAD & Transactivation. The author has an hindex of 35, co-authored 56 publications receiving 9429 citations. Previous affiliations of Jun-ichi Hanai include Harvard University & Japan Society for the Promotion of Science.
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Journal ArticleDOI
Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein Kinase (MAPK) and Phosphatidylinositol-3-kinase (PI3K)/AKT pathways†
Jun-ichi Hanai,Nathaniel Doro,Atsuo T. Sasaki,Atsuo T. Sasaki,Susumu Kobayashi,Lewis C. Cantley,Lewis C. Cantley,Pankaj Seth,Vikas P. Sukhatme +8 more
TL;DR: It is shown that ACL knockdown promotes apoptosis and differentiation, leading to the inhibition of tumor growth in vivo, and it is found that statins, inhibitors of 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, which act downstream of ACL in the cholesterol synthesis pathway, dramatically enhance the anti‐tumor effects of ACL inhibition, even regressing established tumors.
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Lipocalin 2 Diminishes Invasiveness and Metastasis of Ras-transformed Cells
Jun-ichi Hanai,Tadanori Mammoto,Pankaj Seth,Kiyoshi Mori,S. Ananth Karumanchi,Jonathan Barasch,Vikas P. Sukhatme +6 more
TL;DR: Data characterize lipocalin 2 as an epithelial inducer in Ras malignancy and a suppressor of metastasis.
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Magic roundabout, a tumor endothelial marker: Expression and signaling
Pankaj Seth,Yanfeng Lin,Jun-ichi Hanai,Venkatesha Shivalingappa,Mabel P. Duyao,Vikas P. Sukhatme +5 more
TL;DR: The tumor endothelial specific expression of a Robo family member, magic roundabout (MRB), functionally characterized its role in endothelial cell migration and defined a signaling pathway that might mediate this function.
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Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect
Peirang Cao,Jun-ichi Hanai,Preeti Tanksale,Shintaro Imamura,Vikas P. Sukhatme,Stewart H. Lecker +5 more
TL;DR: It is reported here that lovastatin‐induced atrogin‐1 expression and muscle damage in cultured mouse myotubes and zebrafish can be prevented in the presence of geranylgeranol but not farnesol, and the concept that dysfunction of small GTP‐binding proteins lead to statin‐induced muscle damage is supported.
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E1A Inhibits Transforming Growth Factor-β Signaling through Binding to Smad Proteins
TL;DR: The Smad interaction domain (SID) in p300 is determined and it is found that two adjacent regions are required for the interaction, suggesting a novel mechanism whereby E1A antagonizes TGF-β signaling.