J
Jun-ichi Osuga
Researcher at University of Tokyo
Publications - 57
Citations - 6911
Jun-ichi Osuga is an academic researcher from University of Tokyo. The author has contributed to research in topics: Cholesterol & Hormone-sensitive lipase. The author has an hindex of 34, co-authored 57 publications receiving 6598 citations. Previous affiliations of Jun-ichi Osuga include University of Tsukuba.
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Journal ArticleDOI
Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes
Hitoshi Shimano,Naoya Yahagi,Michiyo Amemiya-Kudo,Alyssa H. Hasty,Jun-ichi Osuga,Yoshiaki Tamura,Futoshi Shionoiri,Yoko Iizuka,Ken Ohashi,Kenji Harada,Takanari Gotoda,Shun Ishibashi,Nobuhiro Yamada +12 more
TL;DR: It is demonstrated that SREBP-1 plays a crucial role in the induction of lipogenesis but not cholesterol biosynthesis in liver when excess energy by carbohydrates is consumed.
Journal ArticleDOI
Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity
Jun-ichi Osuga,Shun Ishibashi,Teruaki Oka,Hiroaki Yagyu,Ryu-ichi Tozawa,Akihisa Fujimoto,Futoshi Shionoiri,Naoya Yahagi,Frederic B. Kraemer,Osamu Tsutsumi,Nobuhiro Yamada +10 more
TL;DR: It is shown that HSL is required for spermatogenesis but is not the only enzyme that mediates the hydrolysis of triacylglycerol stored in adipocytes, and that adipocytes were significantly enlarged and the size differences between cell and tissue suggests the heterogeneity of adipocytes.
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Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter
Tomohiro Yoshikawa,Hitoshi Shimano,Michiyo Amemiya-Kudo,Naoya Yahagi,Alyssa H. Hasty,Takashi Matsuzaka,Hiroaki Okazaki,Yoshiaki Tamura,Yoko Iizuka,Ken Ohashi,Jun-ichi Osuga,Kenji Harada,Takanari Gotoda,Satoshi Kimura,Shun Ishibashi,Nobuhiro Yamada +15 more
TL;DR: It is demonstrated that LXR-RXR can modify the expression of genes for lipogenic enzymes by regulating SREBP-1c expression, providing a novel link between fatty acid and cholesterol metabolism.
Journal ArticleDOI
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance
Takashi Matsuzaka,Hitoshi Shimano,Naoya Yahagi,Naoya Yahagi,Toyonori Kato,Ayaka Atsumi,Takashi Yamamoto,Noriyuki Inoue,Mayumi Ishikawa,Sumiyo Okada,Naomi Ishigaki,Hitoshi Iwasaki,Yuko Iwasaki,Tadayoshi Karasawa,Shin Kumadaki,Toshiyuki Matsui,Motohiro Sekiya,Ken Ohashi,Alyssa H. Hasty,Yoshimi Nakagawa,Akimitsu Takahashi,Hiroaki Suzuki,Sigeru Yatoh,Hirohito Sone,Hideo Toyoshima,Jun-ichi Osuga,Nobuhiro Yamada +26 more
TL;DR: Hepatic fatty acid composition is a new determinant for insulin sensitivity that acts independently of cellular energy balance and stress and could be a new therapeutic approach for ameliorating insulin resistance, diabetes and cardiovascular risks, even in the presence of a continuing state of obesity.
Journal ArticleDOI
A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids
Naoya Yahagi,Hitoshi Shimano,Alyssa H. Hasty,Michiyo Amemiya-Kudo,Hiroaki Okazaki,Yoshiaki Tamura,Yoko Iizuka,Futoshi Shionoiri,Ken Ohashi,Jun-ichi Osuga,Kenji Harada,Takanari Gotoda,Ryozo Nagai,Shun Ishibashi,Nobuhiro Yamada +14 more
TL;DR: It is demonstrated that the suppressive effect of PUFA on lipogenic enzyme genes in the liver is caused by a decrease in the mature form of SREBP-1 protein, which is presumably due to the reduced cleavage of SRAB-1 precursor protein.