K
Ken Ohashi
Researcher at University of Tokyo
Publications - 87
Citations - 8854
Ken Ohashi is an academic researcher from University of Tokyo. The author has contributed to research in topics: Cholesterol & Diabetes mellitus. The author has an hindex of 44, co-authored 87 publications receiving 8190 citations. Previous affiliations of Ken Ohashi include University of Tsukuba.
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Journal ArticleDOI
Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes
Hitoshi Shimano,Naoya Yahagi,Michiyo Amemiya-Kudo,Alyssa H. Hasty,Jun-ichi Osuga,Yoshiaki Tamura,Futoshi Shionoiri,Yoko Iizuka,Ken Ohashi,Kenji Harada,Takanari Gotoda,Shun Ishibashi,Nobuhiro Yamada +12 more
TL;DR: It is demonstrated that SREBP-1 plays a crucial role in the induction of lipogenesis but not cholesterol biosynthesis in liver when excess energy by carbohydrates is consumed.
Journal ArticleDOI
Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter
Tomohiro Yoshikawa,Hitoshi Shimano,Michiyo Amemiya-Kudo,Naoya Yahagi,Alyssa H. Hasty,Takashi Matsuzaka,Hiroaki Okazaki,Yoshiaki Tamura,Yoko Iizuka,Ken Ohashi,Jun-ichi Osuga,Kenji Harada,Takanari Gotoda,Satoshi Kimura,Shun Ishibashi,Nobuhiro Yamada +15 more
TL;DR: It is demonstrated that LXR-RXR can modify the expression of genes for lipogenic enzymes by regulating SREBP-1c expression, providing a novel link between fatty acid and cholesterol metabolism.
Journal ArticleDOI
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance
Takashi Matsuzaka,Hitoshi Shimano,Naoya Yahagi,Naoya Yahagi,Toyonori Kato,Ayaka Atsumi,Takashi Yamamoto,Noriyuki Inoue,Mayumi Ishikawa,Sumiyo Okada,Naomi Ishigaki,Hitoshi Iwasaki,Yuko Iwasaki,Tadayoshi Karasawa,Shin Kumadaki,Toshiyuki Matsui,Motohiro Sekiya,Ken Ohashi,Alyssa H. Hasty,Yoshimi Nakagawa,Akimitsu Takahashi,Hiroaki Suzuki,Sigeru Yatoh,Hirohito Sone,Hideo Toyoshima,Jun-ichi Osuga,Nobuhiro Yamada +26 more
TL;DR: Hepatic fatty acid composition is a new determinant for insulin sensitivity that acts independently of cellular energy balance and stress and could be a new therapeutic approach for ameliorating insulin resistance, diabetes and cardiovascular risks, even in the presence of a continuing state of obesity.
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Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements
Tomohiro Yoshikawa,Hitoshi Shimano,Naoya Yahagi,Tomohiro Ide,Michiyo Amemiya-Kudo,Takashi Matsuzaka,Masanori Nakakuki,Sachiko Tomita,Hiroaki Okazaki,Yoshiaki Tamura,Yoko Iizuka,Ken Ohashi,Akimitsu Takahashi,Hirohito Sone,Jun-ichi Osuga,Takanari Gotoda,Shun Ishibashi,Nobuhiro Yamada +17 more
TL;DR: The data suggest that PUFAs could be deeply involved in nutritional regulation of cellular fatty acid levels by inhibiting an LXR-SREBP-1c system crucial for lipogenesis.
Journal ArticleDOI
Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes
Michiyo Amemiya-Kudo,Hitoshi Shimano,Alyssa H. Hasty,Naoya Yahagi,Tomohiro Yoshikawa,Takashi Matsuzaka,Hiroaki Okazaki,Yoshiaki Tamura,Yoko Iizuka,Ken Ohashi,Jun-ichi Osuga,Kenji Harada,Takanari Gotoda,Ryuichiro Sato,Satoshi Kimura,Shun Ishibashi,Nobuhiro Yamada +16 more
TL;DR: Different specificity and affinity of nuclear SREBP-1 and -2 for different target DNAs are demonstrated, explaining a part of the mechanism behind the differential in vivo regulation of cholesterogenic and lipogenic enzymes by SRE BP -2, respectively.