J
Jun Takai
Researcher at Tohoku Pharmaceutical University
Publications - 11
Citations - 505
Jun Takai is an academic researcher from Tohoku Pharmaceutical University. The author has contributed to research in topics: Population & Histamine. The author has an hindex of 7, co-authored 11 publications receiving 412 citations. Previous affiliations of Jun Takai include Tohoku University.
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Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis
TL;DR: Nrf2 has two roles during carcinogenesis, one of which is preventive during tumor initiation and the second that promotes malignant progression, whereas Nrf2 activators are more suited for lung cancer prevention.
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Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung
Hironori Satoh,Takashi Moriguchi,Keiko Taguchi,Jun Takai,Jonathan M. Maher,Takafumi Suzuki,Paul T. Winnard,Venu Raman,Masahito Ebina,Toshihiro Nukiwa,Masayuki Yamamoto +10 more
TL;DR: A novel function for Nrf2 is revealed in the prevention of cancer metastasis, presumably by its ability to preserve the redox balance in the hematopoietic and immune systems.
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The Gata1 5′ region harbors distinct cis-regulatory modules that direct gene activation in erythroid cells and gene inactivation in HSCs
TL;DR: Results indicate that the 3.2-kb interspacing sequences inactivate Gata1 by maintaining DNA-methylation in the HSCs by exerting a cis-repressive function in theHSC-like cell line.
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Whole-Body In Vivo Monitoring of Inflammatory Diseases Exploiting Human Interleukin 6-Luciferase Transgenic Mice.
TL;DR: This study generated a highly sensitive inflammation-monitoring mouse system using a bacterial artificial chromosome clone containing extended flanking sequences of the human interleukin 6 gene (hIL6) locus, in which the luciferase (Luc) reporter gene is integrated ( hIL6-BAC-Luc).
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Histamine and histidine decarboxylase: Immunomodulatory functions and regulatory mechanisms.
Takashi Moriguchi,Jun Takai +1 more
TL;DR: A newly developed histaminergic cell‐monitoring transgenic mouse line (Hdc‐BAC‐GFP) is introduced that serves as a valuable experimental tool to identify the source of histamine and dissect upstream regulatory signals.