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Hironori Satoh

Researcher at Tohoku University

Publications -  20
Citations -  2713

Hironori Satoh is an academic researcher from Tohoku University. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 12, co-authored 17 publications receiving 2281 citations.

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A promoter-level mammalian expression atlas

Alistair R. R. Forrest, +280 more
- 27 Mar 2014 - 
TL;DR: For example, the authors mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene expression across the human body.
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Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis

TL;DR: Nrf2 has two roles during carcinogenesis, one of which is preventive during tumor initiation and the second that promotes malignant progression, whereas Nrf2 activators are more suited for lung cancer prevention.
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Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung

TL;DR: A novel function for Nrf2 is revealed in the prevention of cancer metastasis, presumably by its ability to preserve the redox balance in the hematopoietic and immune systems.
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FANTOM5 CAGE profiles of human and mouse samples

Shuhei Noguchi, +185 more
- 29 Aug 2017 - 
TL;DR: In the FANTOM5 project, transcription initiation events across the human and mouse genomes were mapped at a single base-pair resolution and their frequencies were monitored by CAGE coupled with single-molecule sequencing to represent the consequence of transcriptional regulation in each analyzed state of mammalian cells.
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Myeloid lineage-specific deletion of antioxidant system enhances tumor metastasis.

TL;DR: Results indicate that the antioxidant systems directed by Nrf2 and selenoenzymes contribute to the clearance of ROS in MDSCs, efficiently preventing cancer cell metastasis.