T
Takashi Moriguchi
Researcher at Tohoku Pharmaceutical University
Publications - 60
Citations - 3866
Takashi Moriguchi is an academic researcher from Tohoku Pharmaceutical University. The author has contributed to research in topics: GATA2 & Regulation of gene expression. The author has an hindex of 27, co-authored 57 publications receiving 3096 citations. Previous affiliations of Takashi Moriguchi include Tohoku University & University of Tsukuba.
Papers
More filters
Journal ArticleDOI
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
Eri H. Kobayashi,Takafumi Suzuki,Ryo Funayama,Takeshi Nagashima,Makiko Hayashi,Hiroki Sekine,Nobuyuki Tanaka,Takashi Moriguchi,Hozumi Motohashi,Keiko Nakayama,Masayuki Yamamoto +10 more
TL;DR: It is demonstrated that Nrf2 interferes with lipopolysaccharide-induced transcriptional upregulation of proinflammatory cytokines, including IL-6 and IL-1β, and establishes a molecular basis for an NRF2-mediated anti-inflammation approach.
Journal ArticleDOI
MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion
Chuan Zhang,Takashi Moriguchi,Takashi Moriguchi,Miwako Kajihara,Ritsuko Esaki,Ayako Harada,Homare Shimohata,Hisashi Oishi,Michito Hamada,Naoki Morito,Kazuteru Hasegawa,Takashi Kudo,James Douglas Engel,Masayuki Yamamoto,Satoru Takahashi +14 more
TL;DR: It is reported that MafA mutant mice display intolerance to glucose and develop diabetes mellitus, and analysis revealed that insulin 1, insulin 2, Pdx1, Beta2, and Glut-2 transcripts are diminished in MfA-deficient mice, showing that MAFA is a key regulator of glucose-stimulated insulin secretion in vivo.
Journal ArticleDOI
Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation.
Mingzhan Xue,Naila Rabbani,Naila Rabbani,Hiroshi Momiji,Precious Imbasi,M. Maqsud Anwar,Neil R. Kitteringham,B. Kevin Park,Tomokazu Souma,Takashi Moriguchi,Masayuki Yamamoto,Paul J. Thornalley,Paul J. Thornalley,Paul J. Thornalley +13 more
TL;DR: It is concluded that dicarbonyl stress is countered by up-regulation of Glo1 in the Nrf2 stress-responsive system, protecting protein and DNA from increased damage and preserving cell function.
Journal ArticleDOI
Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis
TL;DR: Nrf2 has two roles during carcinogenesis, one of which is preventive during tumor initiation and the second that promotes malignant progression, whereas Nrf2 activators are more suited for lung cancer prevention.
Journal ArticleDOI
Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung
Hironori Satoh,Takashi Moriguchi,Keiko Taguchi,Jun Takai,Jonathan M. Maher,Takafumi Suzuki,Paul T. Winnard,Venu Raman,Masahito Ebina,Toshihiro Nukiwa,Masayuki Yamamoto +10 more
TL;DR: A novel function for Nrf2 is revealed in the prevention of cancer metastasis, presumably by its ability to preserve the redox balance in the hematopoietic and immune systems.