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Presha Rajbhandari
Researcher at Columbia University
Publications - 15
Citations - 1899
Presha Rajbhandari is an academic researcher from Columbia University. The author has contributed to research in topics: Regulation of gene expression & Medicine. The author has an hindex of 10, co-authored 11 publications receiving 1442 citations. Previous affiliations of Presha Rajbhandari include Columbia University Medical Center.
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Journal ArticleDOI
An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma.
Pavel Sumazin,Xuerui Yang,Hua-Sheng Chiu,Wei-Jen Chung,Archana Iyer,David Llobet-Navas,Presha Rajbhandari,Mukesh Bansal,Paolo Guarnieri,Jose M. Silva,Andrea Califano +10 more
TL;DR: SiRNA silencing of 13 miR-mediated PTEN regulators was sufficient to downregulate PTEN in a 3'UTR-dependent manner and to increase tumor cell growth rates, providing a mechanistic, experimentally validated rationale for the loss of PTEN expression in a large number of glioma samples with an intact PTEN locus.
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A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers
Celine Lefebvre,Presha Rajbhandari,Mariano J. Alvarez,Pradeep Bandaru,Wei Keat Lim,Mai Sato,Kai Wang,Pavel Sumazin,Manjunath Kustagi,Brygida Bisikirska,Katia Basso,Pedro Beltrao,Nevan J. Krogan,Jean-Charles Gautier,Riccardo Dalla-Favera,Andrea Califano +15 more
TL;DR: Assembly of a transcriptional and post‐translational molecular interaction network in B cells, the human B‐cell interactome, reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of proliferation in the germinal center.
Journal ArticleDOI
Transferrin Receptor Is a Specific Ferroptosis Marker
Huizhong Feng,Kenji Schorpp,Jenny Jin,Carrie E. Yozwiak,Benjamin G. Hoffstrom,Aubrianna Decker,Presha Rajbhandari,Michael E. Stokes,Hannah G. Bender,Joleen M. Csuka,Pavan S. Upadhyayula,Peter Canoll,Koji Uchida,Rajesh Kumar Soni,Kamyar Hadian,Brent R. Stockwell +15 more
TL;DR: It is found that anti-TfR1 and anti-malondialdehyde adduct antibodies are effective at staining ferroptotic tumor cells in multiple cell culture and tissue contexts.
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Genome-wide identification of post-translational modulators of transcription factor activity in human B cells
Kai Wang,Masumichi Saito,Masumichi Saito,Brygida Bisikirska,Mariano J. Alvarez,Wei Keat Lim,Wei Keat Lim,Presha Rajbhandari,Qiong Shen,Ilya Nemenman,Ilya Nemenman,Katia Basso,Adam A. Margolin,Adam A. Margolin,Ulf Klein,Riccardo Dalla-Favera,Andrea Califano +16 more
TL;DR: An algorithm, modulator inference by network dynamics (MINDy), is introduced, for the genome-wide identification of post-translational modulators of TF activity within a specific cellular context.
Journal ArticleDOI
Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma.
Presha Rajbhandari,Gonzalo Lopez,Gonzalo Lopez,Claudia Capdevila,Beatrice Salvatori,Jiyang Yu,Jiyang Yu,Ruth Rodriguez-Barrueco,Ruth Rodriguez-Barrueco,Daniel Martinez,Mark Yarmarkovich,Nina Weichert-Leahey,Brian J. Abraham,Mariano J. Alvarez,Archana Iyer,Jo Lynne Harenza,Derek A. Oldridge,Katleen De Preter,Jan Koster,Shahab Asgharzadeh,Shahab Asgharzadeh,Robert C. Seeger,Robert C. Seeger,Jun Wei,Javed Khan,Jo Vandesompele,Pieter Mestdagh,Rogier Versteeg,A. Thomas Look,Richard A. Young,Antonio Iavarone,Anna Lasorella,Jose Silva,John M. Maris,John M. Maris,Andrea Califano +35 more
TL;DR: A framework to determine the downstream effectors of the genetic alterations sustaining neuroblastoma subtypes is presented, which can be easily extended to other tumor types, and nominates TEAD4 as a novel candidate for therapeutic intervention.