Jun-Xu Li

TL;DR: This review summarized recent findings on various pharmacological activities and associative signalling pathways of vitexin and isoviteXin to provide a reference for future research and clinical applications.

TL;DR: This study illustrates the involvement of the Gut microbiota-circHIPK2-astrocyte axis in depression, providing translational evidence that transplantation of the gut microbiota from NLRP3 KO mice may serve as a novel therapeutic strategy for depression.

TL;DR: Current preclinical evidence of interactions between pain and depression generally supports the causative relationship of the two conditions and the analysis proposed to apply domain interplay concept in future model development of pain-depression comorbidity and mechanism studies.

TL;DR: It is demonstrated that circular RNA DYM levels were significantly decreased both in the peripheral blood of patients with MDD and in the two depressive-like mouse models: the chronic unpredictable stress (CUS) and lipopolysaccharide (LPS) models, providing translational evidence that circDYM may be a novel therapeutic target for depression.

TL;DR: Given the psychoactive effects commonly associated with CB1 receptor agonists and antagonists/inverse agonists, allosteric modulation may offer an alternate approach to attain potential therapeutic benefits while avoiding inherent side effects of orthosteric ligands.