J
Junjie Zhu
Researcher at Second Military Medical University
Publications - 9
Citations - 259
Junjie Zhu is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Gankyrin & Medicine. The author has an hindex of 5, co-authored 6 publications receiving 223 citations.
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Journal ArticleDOI
PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression.
Tao Luo,Jing Fu,An Xu,Bo Su,Yibing Ren,Ning Li,Junjie Zhu,Xiaofang Zhao,Rongyang Dai,Jie Cao,Bibo Wang,Wenhao Qin,Jinhua Jiang,Juan Li,Meng-Chao Wu,Gen-Sheng Feng,Yao Chen,Hongyang Wang +17 more
TL;DR: It is reported that PSMD10/gankyrin promotes autophagy in hepatocellular carcinoma (HCC) in response to starvation or stress through 2 complementary routes, and this results present a novel mechanism involving modulation of ATG7 by PS MD10 in sustainingAutophagy, promoting HCC cell survival against starvation or chemotherapy.
Journal ArticleDOI
p28GANK Prevents Degradation of Oct4 and Promotes Expansion of Tumor-Initiating Cells in Hepatocarcinogenesis
You-Wen Qian,Yao Chen,Wen Yang,Jing Fu,Jie Cao,Yi Bin Ren,Junjie Zhu,Bo Su,Tao Luo,Xiao–Fang Zhao,Rong–Yang Dai,Juan–Juan Li,Wen Sun,Meng Chao Wu,Gen-Sheng Feng,Hongyang Wang +15 more
TL;DR: In this paper, the authors quantified levels of p28 GANK (Gankyrin), OV6, and Oct4 in 130 human hepatocellular carcinoma (HCC) samples using immunohistochemistry.
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Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis
Bo Su,Tao Luo,Junjie Zhu,Jing Fu,Xiaofang Zhao,Lei Chen,Hui-Lu Zhang,Yibin Ren,Le-Xing Yu,Xiaojun Yang,Meng-Chao Wu,Gen-Sheng Feng,Shao Li,Yao Chen,Hongyang Wang +14 more
TL;DR: The finding of IL‐1β/IRAK‐1 signaling promoting Gankyrin expression through JNK and NF‐Y/p300/CBP complex provides a fresh view on inflammation‐enhanced hepatocarcinogenesis.
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The Tyrosine Kinase c-Met Contributes to the Pro-tumorigenic Function of the p38 Kinase in Human Bile Duct Cholangiocarcinoma Cells
Rongyang Dai,Juanjuan Li,Jing Fu,Yao Chen,Ruoyu Wang,Xiaofang Zhao,Tao Luo,Junjie Zhu,Yibin Ren,Jie Cao,You-Wen Qian,Ning Li,Ning Li,Hongyang Wang,Hongyang Wang +14 more
TL;DR: It is reported that c-Met, the tyrosine kinase receptor for hepatocyte growth factor (HGF), contributes to the pro-tumorigenic ability of p38 in human cholangiocarcinoma cells.
Journal ArticleDOI
Disturbance of Ca2+ Homeostasis Converts Pro-Met into Non-canonical Tyrosine Kinase p190MetNC in Response to Endoplasmic Reticulum Stress in MHCC97 Cells
Rongyang Dai,Juanjuan Li,Jing Fu,Yao Chen,Le-Xing Yu,Xiaofang Zhao,You-Wen Qian,Hui-Lu Zhang,Haiyang Chen,Yibin Ren,Bo Su,Tao Luo,Junjie Zhu,Hongyang Wang,Hongyang Wang +14 more
TL;DR: P190MetNC compensates for the degradation of p190Metαβ and protects human HCC cells from apoptosis mediated by endoplasmic reticulum (ER) stress and proposes that context-specific processing of c-Met protein is implicated in HCC progression in stressful microenvironments.