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Mark Hochstrasser

Researcher at Yale University

Publications -  196
Citations -  25724

Mark Hochstrasser is an academic researcher from Yale University. The author has contributed to research in topics: Ubiquitin & Proteasome. The author has an hindex of 72, co-authored 184 publications receiving 23250 citations. Previous affiliations of Mark Hochstrasser include University of California, San Francisco & Massachusetts Institute of Technology.

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Journal ArticleDOI

Ubiquitin-dependent protein degradation

Mark Hochstrasser
- 01 Jan 1996 - 
TL;DR: A growing number of cellular regulatory mechanisms are being linked to protein modification by the polypeptide ubiquitin, including key transitions in the cell cycle, class I antigen processing, signal transduction pathways, and receptor-mediated endocytosis.
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Modification of Proteins by Ubiquitin and Ubiquitin-Like Proteins

Oliver Kerscher, +2 more
- 09 Oct 2006 - 
TL;DR: The primary aim of this review is to summarize the latest developments in the understanding of the different Ubl-protein modification systems, including the shared and unique features of these related pathways.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation.

Ping Xu, +9 more
- 03 Apr 2009 - 
TL;DR: It is reported that the unconventional linkages are abundant in vivo and that all non-K63 linkages may target proteins for degradation, and that unconventional polyubiquitin chains are critical for ubiquitin-proteasome system function.
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Mechanism and function of deubiquitinating enzymes.

Alexander Y. Amerik, +1 more
- 29 Nov 2004 - 
TL;DR: Recent discoveries that have led to a better understanding of the mechanisms and physiological roles of this diverse and still poorly understood group of enzymes are focused on.