H
Hugh S. Mason
Researcher at Arizona State University
Publications - 129
Citations - 12182
Hugh S. Mason is an academic researcher from Arizona State University. The author has contributed to research in topics: Antigen & Immunogenicity. The author has an hindex of 53, co-authored 124 publications receiving 11532 citations. Previous affiliations of Hugh S. Mason include University of Arizona & Cornell University.
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Journal ArticleDOI
Expression of hepatitis B surface antigen in transgenic plants.
TL;DR: Because the HBsAg produced in transgenic plants is antigenically and physically similar to theHBsAg particles derived from human serum and recombinant yeast, which are used as vaccines, it is concluded that transgenic Plants hold promise as low-cost vaccine production systems.
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Oral immunization with a recombinant bacterial antigen produced in transgenic plants
TL;DR: Mice immunized by gavage produced serum and gut mucosal anti-LT-B immunoglobulins that neutralized the enterotoxin in cell protection assays and feeding fresh transgenic potato tubers caused oral immunization.
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Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato.
Carol O. Tacket,Hugh S. Mason,Genevieve Losonsky,John D. Clements,Myron M. Levine,Charles J. Arntzen +5 more
TL;DR: The present study was conducted as a proof of principle to determine if humans would also develop a serum and/or mucosal immune response to an antigen delivered in an uncooked foodstuff.
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Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice.
Hugh S. Mason,Judith M. Ball,Jianjian Shi,Xi Jiang,Xi Jiang,Mary K. Estes,Charles J. Arntzen,Charles J. Arntzen +7 more
TL;DR: The results indicate the potential usefulness of plants for production and delivery of edible vaccines, an appropriate technology for developing countries where vaccines are urgently needed.
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Human immune responses to a novel norwalk virus vaccine delivered in transgenic potatoes
Carol O. Tacket,Hugh S. Mason,Genevieve Losonsky,Mary K. Estes,Myron M. Levine,Charles J. Arntzen +5 more
TL;DR: Norwalk virus capsid protein was used as a test antigen, to determine whether immune responses could be generated in volunteers who ingested transgenic potatoes, and 19 of 20 volunteers developed an immune response of some kind, although the level of serum antibody increases was modest.