J
Jürgen M. Lehmann
Researcher at Research Triangle Park
Publications - 56
Citations - 23022
Jürgen M. Lehmann is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Receptor & Peroxisome proliferator-activated receptor. The author has an hindex of 41, co-authored 56 publications receiving 22350 citations. Previous affiliations of Jürgen M. Lehmann include Ludwig Maximilian University of Munich & National Foundation for Cancer Research.
Papers
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Journal Article
The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways.
TL;DR: It is demonstrated that peroxisome proliferators, TZDs, and inducers of CYP3A gene expression exert their biological actions through the activation of orphan nuclear receptors, suggesting a novel regulatory mechanism whereby dietary lipids and their metabolites can regulate gene transcription and impact overall energy balance.
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Antagonism between retinoic acid receptors.
TL;DR: RAR gamma 1, one of the two predominant RAR Gamma isoforms, can inhibit the activity of RAR gamma 2, RAR beta, and endogenous RAR on the beta RARE and may involve competition for the response element as well as direct interaction with other receptors and might be part of a regulatory system contributing to the characteristic tissue distribution of the various RARs.
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Formation of retinoid X receptor homodimers leads to repression of T3 response : hormonal cross talk by ligand-induced squelching
Jürgen M. Lehmann,Xiao-kun Zhang,Gerhart Graupner,Mi-Ock Lee,T. Hermann,Birgit Hoffmann,Magnus Pfahl +6 more
TL;DR: It is reported that RXR-specific retinoids that induce RXR homodimers are effective repressors of the T3 response and ligand-induced squelching may represent an important mechanism by which RXR/RXRs and 9-cis retinoic acid mediate hormonal cross talk among a subfamily of nuclear receptors activated by structurally unrelated ligands.
Patent
Assays for ligands for nuclear receptors
Steven G. Blanchard,Steven A. Kliewer,Jürgen M. Lehmann,Derek J. Parks,Julie B. Stimmel,Timothy M. Willson +5 more
TL;DR: In this article, a method for identifying ligands for nuclear receptors, utilizing scintillation proximity and fluorescence resonance energy transfer (FRET), and methods of using identified ligands.
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Activation of the orphan receptor RIP14 by retinoids
Ann Marie Zavacki,Jürgen M. Lehmann,Wongi Seol,Timothy M. Willson,Steven A. Kliewer,David D. Moore +5 more
TL;DR: Results suggest that RIP14 is the receptor for an as-yet-unidentified retinoid metabolite, although relatively high concentrations of these compounds are required, and no evidence for direct binding of either compound was obtained using several approaches.