J
Jürgen M. Lehmann
Researcher at Research Triangle Park
Publications - 56
Citations - 23022
Jürgen M. Lehmann is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Receptor & Peroxisome proliferator-activated receptor. The author has an hindex of 41, co-authored 56 publications receiving 22350 citations. Previous affiliations of Jürgen M. Lehmann include Ludwig Maximilian University of Munich & National Foundation for Cancer Research.
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Journal ArticleDOI
An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway
Steven A. Kliewer,John T. Moore,Laura E. Wade,Jeff L. Staudinger,Michael A. Watson,Stacey A. Jones,David D. McKee,Beverly B. Oliver,Timothy M. Willson,Rolf Zetterström,Thomas Perlmann,Jürgen M. Lehmann +11 more
TL;DR: The results provide evidence for the existence of a novel steroid hormone signaling pathway with potential implications in the regulation of steroid hormone and sterol homeostasis and the expression of the CYP3A family of steroid hydroxylases and modulates sterol and bile acid biosynthesis in vivo.
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Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway
Jürgen M. Lehmann,Steven A. Kliewer,Linda B. Moore,Tracey Smith-Oliver,Beverly B. Oliver,Jui Lan Su,Scott S. Sundseth,Deborah A. Winegar,Daniel E. Blanchard,Thomas A. Spencer,Timothy M. Willson +10 more
TL;DR: The data provide evidence for a new hormonal signaling pathway that activates transcription in response to oxysterols and suggest that LXRs play a critical role in the regulation of cholesterol homeostasis.
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Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs
TL;DR: It is shown that indomethacin binds and activates peroxisome proliferator-activated receptor γ (PPARγ), a ligand-activated transcription factor known to play a pivotal role in adipogenesis, and several other NSAIDs are also PPARγ ligands and induce adipocyte differentiation of C3H10T1/2 cells.
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Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors
H. Eric Xu,Millard H. Lambert,Valerie G. Montana,Derek J. Parks,Steven G. Blanchard,Peter Brown,Daniel D. Sternbach,Jürgen M. Lehmann,G. Bruce Wisely,Timothy M. Willson,Steven A. Kliewer,Michael V. Milburn +11 more
TL;DR: The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors for fatty acids (FAs) that regulate glucose and lipid homeostasis as mentioned in this paper.
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The structure - Activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones
Timothy M. Willson,Jeffery E. Cobb,David J. Cowan,Robert W. Wiethe,Itzela D. Correa,Shimoga R. Prakash,Kelli D. Beck,Linda B. Moore,Steven A. Kliewer,Jürgen M. Lehmann +9 more