J
Jürgen M. Lehmann
Researcher at Research Triangle Park
Publications - 56
Citations - 23022
Jürgen M. Lehmann is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Receptor & Peroxisome proliferator-activated receptor. The author has an hindex of 41, co-authored 56 publications receiving 22350 citations. Previous affiliations of Jürgen M. Lehmann include Ludwig Maximilian University of Munich & National Foundation for Cancer Research.
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Journal ArticleDOI
A peroxisome proliferator-activated receptor γ ligand inhibits adipocyte differentiation
Jennifer L. Oberfield,Jon L. Collins,Christopher P. Holmes,Donna M. Goreham,Joel P. Cooper,Jeffery E. Cobb,James M. Lenhard,Emily A. Hull-Ryde,Christopher P. Mohr,Steven G. Blanchard,Derek J. Parks,Linda B. Moore,Jürgen M. Lehmann,Kelli D. Plunket,Ann B. Miller,Michael V. Milburn,Steven A. Kliewer,Timothy M. Willson +17 more
TL;DR: The peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that regulate glucose and lipid homeostasis as mentioned in this paper and play a central role in the regulation of adipogenesis and is the molecular target for the 2,4-thiazolidinedione class of antidiabetic drugs.
Journal Article
Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells.
Jeffrey M. Gimble,Claudius E. Robinson,Claudius E. Robinson,Xiying Wu,Katherine A. Kelly,Katherine A. Kelly,Brenda R. Rodriguez,Steven A. Kliewer,Jürgen M. Lehmann,David C. Morris +9 more
TL;DR: Thiazolidinedione directly regulates bone marrow stromal cell differentiation; induced PPAR gamma expression may play a key regulatory role in this process.
Journal ArticleDOI
4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma.
TL;DR: The results demonstrate the existence of high-affinity ligands for the ERR family of orphan receptors, and identify 4-OHT as a molecule that can regulate the transcriptional activity of ERRγ.
Journal ArticleDOI
COUP orphan receptors are negative regulators of retinoic acid response pathways.
TL;DR: The data suggest that the COUP receptors are a novel class of RAR and RXR regulators that can restrict RA signaling to certain elements, and may play an important role in cell- or tissue-specific repression of subsets of RA-sensitive programs during development and in the adult.
Journal ArticleDOI
A Retinoic Acid Receptor-Specific Element Controls the Retinoic Acid Receptor-β Promoter
Birgit Hoffmann,Jürgen M. Lehmann,Xiao-kun Zhang,T. Hermann,Matthias Husmann,Gerhart Graupner,Magnus Pfahl +6 more
TL;DR: It is shown here that this RA receptor-β (RARβ) gene promoter that is controlled by RA is activated by endogenous RARs and RARβ, but cannot be regulated by thyroid hormone receptors and other known nuclear receptors.