Benjamin S. Schuster

TL;DR: This work prepared polymeric nanoparticles densely coated with low molecular weight polyethylene glycol to minimize muco-adhesion, and compared their transport to that of uncoated particles in human respiratory mucus, which was collected from the endotracheal tubes of surgical patients with no respiratory comorbidities.

TL;DR: A single-protein-based platform for generating synthetic membraneless compartments that is capable of enzymatically-triggered alterations to phase behavior and of recruiting and concentrating cargo proteins is presented.

TL;DR: It is demonstrated that particle penetration within the brain tumor parenchyma improves therapeutic efficacy and the use of drug-loaded brain-penetrating nanoparticles is a promising approach to achieve sustained and more uniform drug delivery to treat aggressive gliomas and potentially other brain disorders.

TL;DR: A careful head-to-head comparison of MAP versus MPP following inhalation is provided and a long-standing dogma that favored the use of MAP for pulmonary drug delivery is challenged.

TL;DR: This work explores a model protein, the disordered N-terminal domain of LAF-1, and highlights how three key features of the sequence control the protein’s propensity to phase-separate, and identifies a region of the RGG domain that has high contact probability and is highly conserved between species; deletion of this region significantly disrupts phase separation in vitro and in vivo.