J
Justo Cobo
Researcher at University of Jaén
Publications - 492
Citations - 3545
Justo Cobo is an academic researcher from University of Jaén. The author has contributed to research in topics: Hydrogen bond & Molecule. The author has an hindex of 26, co-authored 484 publications receiving 3148 citations.
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Journal ArticleDOI
Synthesis of new indeno[1,2-e]pyrimido[4,5-b][1,4]diazepine-5,11-diones as potential antitumor agents.
Braulio Insuasty,Fabián Orozco,Carolina Lizarazo,Jairo Quiroga,Rodrigo Abonia,Michael B. Hursthouse,Manuel Nogueras,Justo Cobo +7 more
TL;DR: Novel racemic indeno[1,2-e]pyrimido[4,5-b][1,4]diazepine-5,11-diones 3-29 were obtained regioselectivily from the reaction of 5,6-diamino-3,4-dihydropyrimidin-4-ones 1 and 2-arylideneindandiones 2 as reagents.
Journal ArticleDOI
A straightforward synthesis of pyrimido[4,5-b]quinoline derivatives assisted by microwave irradiation
Jairo Quiroga,Jorge Trilleras,Braulio Insuasty,Rodrigo Abonia,Manuel Nogueras,Antonio Marchal,Justo Cobo +6 more
TL;DR: Several pyrimido[4,5-b]quinolines, flavin analogues, have been prepared by assisted microwave intramolecular cyclization of N4substituted-2,4-diamino-6-chloropyrimidine-5-carbaldehydes.
Journal ArticleDOI
Generation of pyrrolo[2,3-d]pyrimidines. Unexpected products in the multicomponent reaction of 6-aminopyrimidines, dimedone, and arylglyoxal
Jairo Quiroga,Paola Acosta,Silvia Cruz,Rodrigo Abonia,Braulio Insuasty,Manuel Nogueras,Justo Cobo +6 more
TL;DR: A series of 6-aryl-5-(1-cyclohexen-1-yl)pyrrolo[2,3-d]pyrimidines 9a-q were obtained by the three-component reaction between 6-aminopyridines 6, 7, 8, dimedone 2, and arylglyoxal 5a,b.
Journal ArticleDOI
Synthesis and in Vitro Antitumor Activity of a Novel Series of 2-Pyrazoline Derivatives Bearing the 4-Aryloxy-7-chloroquinoline Fragment
TL;DR: The 2-pyrazoline derivatives bearing the 4-aryloxy-7-chloroquinoline fragment are considered to be useful leads for the rational design of new antitumor agents.
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6-(Aryldiazenyl)pyrazolo[1,5-a]pyrimidines as Strategic Intermediates for the Synthesis of Pyrazolo[5,1-b]purines.
TL;DR: A microwave-assisted approach for the regioselective synthesis of functionalized 6-(aryldiazenyl)pyrazolo[1,5-a]pyrimidin-7-amines from the cyclization of 3-oxo-2-(2-arylhydrazinylidene)butanenitriles with 5-amino-1H-pyrazoles under solvent-free conditions has been developed.