Justo Cobo

TL;DR: A versatile synthetic method has been developed for the formation of variously substituted polycyclic pyrimidoazepine derivatives by nucleophilic substitution reactions on the corresponding chloro-substituted compounds; the reactions can be promoted either by conventional heating in basic solutions or by microwave heating in solvent-free systems.

TL;DR: In this article, the tricomponent reaction of 4,5,6triaminopyrimidine 1, 1,3-indandione 2 and aromatic aldehydes 3a-f was used to obtain 11-amino-6-aryl-6,7-dihydroindeno[1,2-e] pyrimido[4,5b][1,4]diazepin-5(5aH)-ones.

TL;DR: There are no direction-specific intermolecular interactions of any kind in the structure of (2SR,4RS)-7-bromo-2-exo-phenyl-2,3,4,5-tetrahydro-1H-1,4-epoxy-1-benzazepine, C(16)H(14)BrNO, (IV).

TL;DR: In this article, it was shown that the formylation of 6-aminopyrimidines occurs only when there is no contribution of hetero-aromaticity in the pyrimidine ring and that the corresponding pyrimidoformamides are formed in heteroaromatic pyrimids.

TL;DR: Two spiro[indoline-3,3'-pyrrolizine] derivatives have been synthesized in good yield with high regio- and stereospecificity using one-pot reactions between readily available starting materials, namely L-proline, substituted 1H-indole-2,3-diones and electron-deficient alkenes.