J
Justo Cobo
Researcher at University of Jaén
Publications - 492
Citations - 3545
Justo Cobo is an academic researcher from University of Jaén. The author has contributed to research in topics: Hydrogen bond & Molecule. The author has an hindex of 26, co-authored 484 publications receiving 3148 citations.
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Synthesis of novel hydropyrazolopyridine derivatives in solvent-free conditions via benzotriazole methodology
TL;DR: In this paper, the reaction between 5-[ N -(benzotriazol-1-ylmethyl)amino]-3- tert -butyl- 1-phenylpyrazole or 5-amino-4-(benzoteitriazol 1-yl methyl)-3]- tert-butyl 1-phosphyl pyrazole with some unactivated and electron-rich alkenes has followed heterocyclization reactions to yield hydropyrazolopyridines, under solvent-free conditions, as predicted by benzotri
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Unexpected intramolecular cyclization of some 2'-aminochalcones to indolin-3-ones mediated by Amberlyst®-15
Rodrigo Abonia,Paola Cuervo,Juan Camilo Castillo,Braulio Insuasty,Jairo Quiroga,Manuel Nogueras,Justo Cobo +6 more
TL;DR: In this paper, the intramolecular cyclization of 2′-aminochalcones derived from 2- and 4-pyridinecarboxaldehydes was carried out in the presence of Amberlyst®-15/AcOH media.
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Structure activity relationships and the binding mode of quinolinone-pyrimidine hybrids as reversal agents of multidrug resistance mediated by P-gp.
Jerónimo Laiolo,Priscila Ailin Lanza,Oscar Parravicini,Cecilia Barbieri,Daniel Insuasty,Daniel Insuasty,Justo Cobo,D. Mariano A. Vera,Ricardo D. Enriz,María Cecilia Carpinella +9 more
TL;DR: In this paper, a panel of quinolin-2-one-pyrimidine hybrids was investigated to find non-toxic and effective P-gp inhibitors, and two of them significantly increased intracellular doxorubicin and rhodamine 123 accumulation.
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A Simple Two-Step Sequence for the Synthesis of Novel 4-Aryl-4,5-dihydro-6H-[1,3]dioxolo[4,5-h]pyrrolo[1,2-a][1]benzazepin-6-ones from 6-Amino-3,4-methylenedioxyacetophenone
TL;DR: In this article, a two-step short procedure for the synthesis of novel 6H]-1,3]dioxolobenzo[4,5-h]pyrrolo[1,2-a][1]benzazepin-6-one derivatives promoted by commercial phosphoric acid is provided.
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Synthesis, Photophysical Properties, and Metal-Ion Recognition Studies of Fluoroionophores Based on 1-(2-Pyridyl)-4-Styrylpyrazoles.
TL;DR: A convenient access toward novel fluoroionophores based on 1-(2-pyridyl)-4-styrylpyrazoles (PSPs) substituted at position 3 with donor or acceptor aryl groups is reported.