K
K. M. Muraleedharan
Researcher at Indian Institute of Technology Madras
Publications - 49
Citations - 802
K. M. Muraleedharan is an academic researcher from Indian Institute of Technology Madras. The author has contributed to research in topics: Artemisinin & Carboxylic acid. The author has an hindex of 12, co-authored 47 publications receiving 751 citations. Previous affiliations of K. M. Muraleedharan include University of Mississippi & Indian Institute of Chemical Technology.
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Halo- and selenolactonisation: the two major strategies for cyclofunctionalisation
TL;DR: Van Tamelen and Shamma as discussed by the authors proposed that halolactonisation arise by the intramolecular carboxylic acid-mediated opening of the initially formed halonium ion intermediate.
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Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria.
Mitchell A. Avery,K. M. Muraleedharan,Prashant V. Desai,Achintya K Bandyopadhyaya,Marise M Furtado,Babu L. Tekwani +5 more
TL;DR: The study suggests the possibility of developing artemisinin analogues as potential drug candidates against both malaria and leishmaniasis.
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Progress in the development of peroxide-based anti-parasitic agents.
TL;DR: Progress made in the past decade pertaining to the development of anti-parasitic agents based on artemisinin is presented and an outline on its seco analogs and art Artemisinin bundles are given for a broader perspective on structure-activity relationships.
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Transformation of artemisinin by Cunninghamella elegans
TL;DR: 7β-hydroxyartemisinin, obtained from microbial transformation, is utilized as a semi-synthetic precursor for the synthesis of novel 7β-substituted art Artemisinin anti-malarial agents.
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Microbial transformation of artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger
Igor A. Parshikov,Brushapathy Miriyala,K. M. Muraleedharan,Mitchell A. Avery,John S. Williamson +4 more
TL;DR: Transformation of the anti-malarial drug artemisinin by the fungi Eurotium amstelodami and Aspergillus niger were investigated and metabolites from each fungal extract were isolated and identified using mass spectrometry and nuclear magnetic resonance.