K
Kalliopi Tsafou
Researcher at Broad Institute
Publications - 26
Citations - 9828
Kalliopi Tsafou is an academic researcher from Broad Institute. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 12, co-authored 21 publications receiving 7941 citations. Previous affiliations of Kalliopi Tsafou include Foundation for Research & Technology – Hellas & Technical University of Denmark.
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STRING v10: protein–protein interaction networks, integrated over the tree of life
Damian Szklarczyk,Andrea Franceschini,Stefan Wyder,Kristoffer Forslund,Davide Heller,Jaime Huerta-Cepas,Milan Simonovic,Alexander Roth,Alberto Santos,Kalliopi Tsafou,Michael Kuhn,Peer Bork,Lars Juhl Jensen,Christian von Mering +13 more
TL;DR: H hierarchical and self-consistent orthology annotations are introduced for all interacting proteins, grouping the proteins into families at various levels of phylogenetic resolution in the STRING database.
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DISEASES: text mining and data integration of disease-gene associations.
TL;DR: The DISEASES resource, which integrates the results from text mining with manually curated disease-gene associations, cancer mutation data, and genome-wide association studies from existing databases, is developed.
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COMPARTMENTS: unification and visualization of protein subcellular localization evidence
Janos X. Binder,Sune Pletscher-Frankild,Kalliopi Tsafou,Christian Stolte,Seán I. O'Donoghue,Reinhard Schneider,Lars Juhl Jensen +6 more
TL;DR: The COMPARTMENTS resource is presented, which integrates all sources listed above as well as the results of automatic text mining, and all localization evidence is mapped onto common protein identifiers and Gene Ontology terms.
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Autism genes converge on asynchronous development of shared neuron classes
Bruna S. Paulsen,Silvia Velasco,Amanda J. Kedaigle,Martina Pigoni,Giorgia Quadrato,Anthony J. Deo,Xian Adiconis,Ana Uzquiano,Rafaela Sartore,Sung Min Yang,Sean Simmons,P Symvoulidis,Kwanho Kim,Kalliopi Tsafou,Archana Podury,Catherine Abbate,Ashley Tucewicz,Samantha N Smith,Alexandre Albanese,Lindy E. Barrett,Neville E. Sanjana,Xi Shi,Kwang-Ho Chung,Kasper Lage,Edward S. Boyden,Aviv Regev,Joshua Z. Levin,Paola Arlotta +27 more
TL;DR: In this paper , the authors used organoid models of the human cerebral cortex to identify cell-type-specific developmental abnormalities that result from haploinsufficiency in three ASD risk genes, SUV420H1 (also known as KMT5B), ARID1B, and CHD8, in multiple cell lines from different donors.
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Comprehensive comparison of large-scale tissue expression datasets
Alberto Santos,Kalliopi Tsafou,Christian Stolte,Sune Pletscher-Frankild,Seán I. O'Donoghue,Seán I. O'Donoghue,Lars Juhl Jensen +6 more
TL;DR: A comprehensive evaluation of tissue expression data from a variety of experimental techniques is presented and it is found that most datasets support the assumed but not demonstrated distinction between tissue-specific and ubiquitous expression.