K
Kan Chen
Researcher at Erasmus University Rotterdam
Publications - 18
Citations - 588
Kan Chen is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Cell growth & Gene knockdown. The author has an hindex of 11, co-authored 18 publications receiving 437 citations. Previous affiliations of Kan Chen include Minzu University of China & Zhejiang Sci-Tech University.
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Journal ArticleDOI
Calcineurin Inhibitors Stimulate and Mycophenolic Acid Inhibits Replication of Hepatitis E Virus
Yijin Wang,Xinying Zhou,Yannick Debing,Kan Chen,Kan Chen,Luc J. W. van der Laan,Johan Neyts,Harry L.A. Janssen,Harry L.A. Janssen,Herold J. Metselaar,Maikel P. Peppelenbosch,Qiuwei Pan +11 more
TL;DR: These findings should be considered when physicians select immunosuppressive therapies for recipients of organ transplants who are infected with HEV, and the combination of MPA and ribavirin had a greater ability to inhibit HEV replication than MPA or ribavirus alone.
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Unphosphorylated ISGF3 drives constitutive expression of interferon-stimulated genes to protect against viral infections.
Wenshi Wang,Yuebang Yin,Lei Xu,Junhong Su,Fen Huang,Yijin Wang,Patrick P.C. Boor,Kan Chen,W. Wang,Wanlu Cao,Xinying Zhou,Pengyu Liu,Luc J. W. van der Laan,Jaap Kwekkeboom,Maikel P. Peppelenbosch,Qiuwei Pan +15 more
TL;DR: It is found that IFN-independent ISG expression was detectable in immortalized cell lines, primary intestinal and liver organoids, and liver tissues, and it is suggested that the U-ISGF3 complex is both necessary and sufficient for constitutive ISGs expression and antiviral immunity under homeostatic conditions.
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SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma.
Pratika Y. Hernanda,Kan Chen,Kan Chen,Asha M. Das,Kostandinos Sideras,Wenshi Wang,Juan Li,Wanlu Cao,S.J.A. Bots,L L Kodach,R.A. de Man,Jan N. M. IJzermans,Harry L.A. Janssen,Harry L.A. Janssen,Andrew P. Stubbs,Dave Sprengers,Marco J. Bruno,Herold J. Metselaar,Timo L.M. ten Hagen,Jaap Kwekkeboom,Maikel P. Peppelenbosch,Qiuwei Pan +21 more
TL;DR: A highly non-canonical tumor-promoting function of SMAD4 in HCC is revealed and its potential as an outcome predictor for patient stratification and a target for personalized therapeutic development is highlighted.
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Advancing the understanding of NAFLD to hepatocellular carcinoma development: From experimental models to humans.
TL;DR: This review will comprehensively describe the current in vitro and mouse models for studying NAFLD/NASH/HCC, and further emphasize their applications and possible future improvement for better understanding the molecular mechanisms involved in the cascade ofNAFLD to HCC progression.
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LGR5 marks targetable tumor-initiating cells in mouse liver cancer
Wanlu Cao,Meng Li,Jiaye Liu,Shaoshi Zhang,Lisanne Noordam,Monique M A Verstegen,Ling Wang,Buyun Ma,Shan Li,Wenshi Wang,Michiel Bolkestein,Michael Doukas,Kan Chen,Kan Chen,Kan Chen,Zhongren Ma,Marco J. Bruno,Dave Sprengers,Jaap Kwekkeboom,Luc J. W. van der Laan,Ron Smits,Maikel P. Peppelenbosch,Qiuwei Pan +22 more
TL;DR: The enrichment of L GR5 expressing cells, a well-recognized stem cell marker, in mouse liver tumors, and the upregulation of LGR5 expression in human hepatocellular carcinoma are reported, representing a viable therapeutic target for combating liver cancer.