Lan N. Tu

TL;DR: In an attempt to correlate the in vivo findings to previously used in vitro models, it is determined that siRNA knockdown or the absence of TSPO in different mouse and human steroidogenic cell lines had no effect on steroidogenesis.

TL;DR: Identification of Michael acceptor-centric pharmacophores among diversified compounds demonstrates that a systematic approach to discover and develop Michaelacceptor-based TrxR inhibitors is feasible.

TL;DR: Results show that the pharmacological effect of PK11195 on steroidogenesis is not mediated through TSPO, and both control and control MA-10:Tspo+/+ cells responded in a similar dose-dependent manner showing increases in progesterone production.

TL;DR: Results demonstrate the first experimental evidence that TSPO can affect mitochondrial energy homeostasis through modulation of FAO, a function that appears to be consistent with high levels of TSPo expression observed in cell types active in lipid storage/metabolism.

TL;DR: Gas- and liquid chromatography/mass spectrometry-based profiling of lipidomic and primary metabolism changes in the liver and plasma revealed that systemic mechanisms leading to steatosis and hepatitis in this non-obese NAFLD model were driven by a combination of effects directed by elevated free cholesterol, cholesterol esters and cholic acid, and associated changes to metabolism of sphingomyelins and phosphatidylcholines.