Kannan Umadevi Venkataraju

TL;DR: A pipeline for high-speed acquisition of brain activity at cellular resolution through profiling immediate early gene expression using immunostaining and light-sheet fluorescence imaging, followed by automated mapping and analysis of activity by an open-source software program that is widely applicable to different experimental paradigms, including animal species for which transgenic activity reporters are not readily available.

TL;DR: An automated method is described that achieves high-throughput fluorescence imaging of mouse brains by integrating two-photon microscopy and tissue sectioning, which opens the door to routine systematic studies of neuroanatomy in mouse models of human brain disorders.

TL;DR: An unexpected cortical organizing principle is discovered: sensory-motor areas are dominated by output-modulating parvalbumin-positive interneurons, whereas association, including frontal, areas aredominated by input-modifying somatostatin-positiveinterneuron areas.

TL;DR: The results lay a foundation for understanding the input/output structure of the midbrain dopamine circuit and demonstrate that dopamine neurons projecting to the posterior striatum constitute a unique class of dopamine neurons regulated by different inputs.

TL;DR: In this paper, the authors apply an automated method for mapping brain activation in the mouse in order to probe how sex-specific social behaviors are represented in the male brain using the immediate-early-gene c-fos, a marker of neuronal activation, visualized by serial two-photon tomography.