K
Kanury V. S. Rao
Researcher at Purdue University
Publications - 82
Citations - 3202
Kanury V. S. Rao is an academic researcher from Purdue University. The author has contributed to research in topics: Protease & HIV-1 protease. The author has an hindex of 29, co-authored 82 publications receiving 2886 citations. Previous affiliations of Kanury V. S. Rao include University of Hyderabad & Translational Health Science and Technology Institute.
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The Baylis–Hillman reaction: a novel source of attraction, opportunities, and challenges in synthetic chemistry
TL;DR: The Baylis-Hillman reaction is a successful, useful, and atom-economical carbon-carbon bond forming reaction, which has grown from an obscure level to the level of high synthetic popularity due to its operational simplicity and also due to the enormous applications of the Baylis/Hillman adducts in organic synthesis.
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Genome-wide Analysis of the Host Intracellular Network that Regulates Survival of Mycobacterium tuberculosis
Dhiraj Kumar,L. M. Nath,Md. Azhar Kamal,Ankur Varshney,Avinash Jain,Sarman Singh,Kanury V. S. Rao +6 more
TL;DR: A genome-wide siRNA screen to identify host factors that regulated pathogen load in human macrophages infected with a virulent strain of Mycobacterium tuberculosis identified 275 molecules that were all found to functionally associate with each other through a dense network of interactions.
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Mycobacterium tuberculosis-Driven Targeted Recalibration of Macrophage Lipid Homeostasis Promotes the Foamy Phenotype
TL;DR: It is found that Mtb induces the foamy phenotype via targeted manipulation of host cellular metabolism to divert the glycolytic pathway toward ketone body synthesis, and pharmacological targeting of pathways mediating this host-pathogen metabolic crosstalk provides a potential strategy for developing tuberculosis chemotherapy.
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The Strength of Receptor Signaling Is Centrally Controlled through a Cooperative Loop between Ca2+ and an Oxidant Signal
TL;DR: It is shown here that the Ca2+ and reactive oxygen intermediates generated upon BCR activation rapidly engage in a cooperative interaction that acts in a feedback manner to amplify the early signal generated.
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Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation
Arun K. Ghosh,Jun Takayama,Kanury V. S. Rao,Kiira Ratia,Rima Chaudhuri,Debbie C. Mulhearn,Hyun Lee,Daniel B. Nichols,Surendranath Baliji,Susan C. Baker,Michael E. Johnson,Andrew D. Mesecar +11 more
TL;DR: A protein-ligand X-ray structure of 15 g-bound SARS-CoV PLpro and a corresponding model of 15 h docked to PLpro provide intriguing molecular insight into the ligand-binding site interactions.