K
Karen Bourque
Researcher at Genetics Institute, Inc.
Publications - 4
Citations - 7552
Karen Bourque is an academic researcher from Genetics Institute, Inc.. The author has contributed to research in topics: T cell & Antigen-presenting cell. The author has an hindex of 4, co-authored 4 publications receiving 6677 citations.
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Journal ArticleDOI
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
Gordon J. Freeman,Andrew J. Long,Yoshiko Iwai,Karen Bourque,Tatyana Chernova,Hiroyuki Nishimura,Lori Fitz,Nelly Malenkovich,Taku Okazaki,Michael C. Byrne,Heidi F. Horton,Lynette A. Fouser,Laura L. Carter,Vincent Ling,Michael R Bowman,Beatriz M. Carreno,Mary Collins,Clive Wood,Tasuku Honjo +18 more
TL;DR: It is reported here that the ligand of PD-1 (PD-L1), an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells, is a member of the B7 gene family.
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PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Yvette Latchman,Clive Wood,Tatyana Chernova,Divya Chaudhary,Madhuri Borde,Irene Chernova,Yoshiko Iwai,Andrew J. Long,Julia A. Brown,Raquel A. Nunes,Edward A. Greenfield,Karen Bourque,Vassiliki A. Boussiotis,Laura L. Carter,Beatriz M. Carreno,Nelly Malenkovich,Hiroyuki Nishimura,Taku Okazaki,Tasuku Honjo,Arlene H. Sharpe,Gordon J. Freeman +20 more
TL;DR: These studies show overlapping functions of PD-L1 andPD-L2 and indicate a key role for the PD- L–PD-1 pathway in regulating T cell responses.
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IL-21 effects on human IgE production in response to IL-4 or IL-13.
Wood Nancy L,Karen Bourque,Debra D. Donaldson,Mary Collins,Donata Vercelli,Samuel J. Goldman,Marion T. Kasaian +6 more
TL;DR: It is indicated that IL-21 may influence the production of both human IgE and IgG4, and thus contribute to the regulation of atopic reactions.
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Identification of a human follicular dendritic cell molecule that stimulates germinal center B cell growth.
TL;DR: It is suggested that the primary function of FDCs in the GC is to stimulate B cell growth, and an FDC signal molecule, 8D6 Ag, may be an important molecule to mediate this function.