Michael C. Byrne

TL;DR: It is reported here that the ligand of PD-1 (PD-L1), an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells, is a member of the B7 gene family.

TL;DR: A number of genes that antagonize signaling, including members of the SOCS family, may contribute to their anergic phenotype and GITR abrogated suppression, demonstrating a functional role for this receptor in regulating the CD4(+)CD25(+) T cell subset.

TL;DR: It is shown that the Ca2+-regulated transcription factor NFAT has an integral role in both aspects of lymphocyte function and in the absence of AP-1, NFAT imposes a genetic program of lymphocytes anergy that counters the program of productive activation mediated by the cooperative NFAT:AP-1 complex.

TL;DR: Cytometric single-cell analysis of Th cell cytokine production revealed that IL-17 cannot be categorized as either Th1 or Th2 cytokine, and almost allIL-17-producing Th cells simultaneously produced TNF-α and most IL- 17+ Th cells also produced GM-CSF, also observed in humans.

TL;DR: XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas that is essential for liver growth and specific target genes of XBP- 1 in the liver were identified as alphaFP, which may be a regulator of hepatocyte growth, and three acute phase protein family members.