K
Karen R. Kilcoyne
Researcher at University of Edinburgh
Publications - 16
Citations - 572
Karen R. Kilcoyne is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Leydig cell & Testosterone. The author has an hindex of 10, co-authored 15 publications receiving 409 citations. Previous affiliations of Karen R. Kilcoyne include Medical Research Council.
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Journal ArticleDOI
Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells
Karen R. Kilcoyne,Lee B. Smith,Nina Atanassova,Sheila Macpherson,Chris McKinnell,Sander van den Driesche,Matthew S. Jobling,Thomas Chambers,Karel De Gendt,Guido Verhoeven,Laura O’Hara,Sophie Platts,Luiz R. França,Nathalia de Lima e Martins Lara,Richard A. Anderson,Richard M. Sharpe +15 more
TL;DR: It is shown that testosterone levels during fetal masculinization can (re)program adult testosterone levels through effects on stem cells, which develop into adult Leydig cells (the source of testosterone) after puberty, for the first time.
Journal ArticleDOI
Experimentally induced testicular dysgenesis syndrome originates in the masculinization programming window
Sander van den Driesche,Karen R. Kilcoyne,Ida Wagner,Diane Rebourcet,Ashley K Boyle,Rod T. Mitchell,Chris McKinnell,Sheila Macpherson,Roland Donat,Chitranjan J Shukla,Anne Jørgensen,Ewa Rajpert-De Meyts,Niels E. Skakkebæk,Richard M. Sharpe +13 more
TL;DR: The testicular dysgenesis syndrome (TDS) hypothesis is tested using a rat model involving gestational exposure to dibutyl phthalate (DBP), which suppresses testosterone production by the fetal testis, and it is shown that DBP exposure in the MPW causes reduced AGD, focal testicular Dysgenesis, and TDS disorders.
Journal ArticleDOI
Ibuprofen results in alterations of human fetal testis development
Millissia Ben Maamar,Laurianne Lesné,Kristin Hennig,Christèle Desdoits-Lethimonier,Karen R. Kilcoyne,Isabelle Coiffec,Antoine Rolland,Cécile Chevrier,David Møbjerg Kristensen,David Møbjerg Kristensen,Vincent Lavoué,Jean-Philippe Antignac,Bruno Le Bizec,Nathalie Dejucq-Rainsford,Rod T. Mitchell,Séverine Mazaud-Guittot,Bernard Jégou,Bernard Jégou +17 more
TL;DR: It is concluded that, at concentrations relevant to human exposure and within a particular narrow ‘early window’ of sensitivity within first trimester, ibuprofen causes direct endocrine disturbances in the human fetal testis and alteration of the germ cell biology.
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Effect of environmental and pharmaceutical exposures on fetal testis development and function: a systematic review of human experimental data
TL;DR: The effects of environmental, pharmaceutical and lifestyle factors in experimental systems involving exposure of human fetal testis tissues and cells are presented and consistent effects of analgesic and phthalate exposure on human fetal germ cell development are demonstrated in experimental models, correlating with evidence from epidemiological studies and animal models.
Journal ArticleDOI
Effects of environmental Bisphenol A exposures on germ cell development and Leydig cell function in the human fetal testis.
Soria Eladak,Soria Eladak,Delphine Moison,Delphine Moison,Marie-Justine Guerquin,Marie-Justine Guerquin,Gabriele Matilionyte,Karen R. Kilcoyne,Thierry N’Tumba-Byn,Thierry N’Tumba-Byn,Sébastien Messiaen,Sébastien Messiaen,Yoann Deceuninck,Stéphanie Pozzi-Gaudin,Alexandra Benachi,Gabriel Livera,Gabriel Livera,Jean-Philippe Antignac,Roderick Mitchell,Virginie Rouiller-Fabre,Virginie Rouiller-Fabre,René Habert,René Habert +22 more
TL;DR: Exposure to BPA at environmentally relevant concentrations impairs germ cell development in first trimester human fetal testis, whilst gonadotrophin-stimulated testosterone production was unaffected in both first and second trimester testis.