K
Karen Sheikh
Researcher at Cornell University
Publications - 3
Citations - 2299
Karen Sheikh is an academic researcher from Cornell University. The author has contributed to research in topics: Cancer & Exome sequencing. The author has an hindex of 3, co-authored 3 publications receiving 1947 citations.
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Journal ArticleDOI
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
Christopher E. Barbieri,Sylvan C. Baca,Sylvan C. Baca,Michael S. Lawrence,Francesca Demichelis,Francesca Demichelis,Mirjam Blattner,Jean Philippe Theurillat,Thomas A. White,Petar Stojanov,Eliezer M. Van Allen,Eliezer M. Van Allen,Nicolas Stransky,Elizabeth Nickerson,Sung Suk Chae,Gunther Boysen,Daniel Auclair,Robert C. Onofrio,Kyung Park,Naoki Kitabayashi,Theresa Y. MacDonald,Karen Sheikh,Terry Vuong,Candace Guiducci,Kristian Cibulskis,Andrey Sivachenko,Scott L. Carter,Gordon Saksena,Douglas Voet,Wasay M. Hussain,Alex H. Ramos,Alex H. Ramos,Wendy Winckler,Michelle C Redman,Kristin Ardlie,Ashutosh K. Tewari,Juan Miguel Mosquera,Niels J. Rupp,Peter J. Wild,Holger Moch,Colm Morrissey,Peter S. Nelson,Peter S. Nelson,Philip W. Kantoff,Stacey Gabriel,Todd R. Golub,Matthew Meyerson,Eric S. Lander,Eric S. Lander,Gad Getz,Mark A. Rubin,Levi A. Garraway +51 more
TL;DR: SPOP mutations may define a new molecular subtype of prostate cancer, with mutations involving the SPOP substrate-binding cleft in 6–15% of tumors across multiple independent cohorts.
Journal ArticleDOI
Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets
Himisha Beltran,David S. Rickman,Kyung Park,Sung Suk Chae,Andrea Sboner,Theresa Y. MacDonald,Yuwei Wang,Karen Sheikh,Stéphane Terry,Scott T. Tagawa,Rajiv Dhir,Joel B. Nelson,Alexandre de la Taille,Yves Allory,Mark Gerstein,Sven Perner,Kenneth J. Pienta,Arul M. Chinnaiyan,Arul M. Chinnaiyan,Yuzhuo Wang,Colin Collins,Martin E. Gleave,Francesca Demichelis,Francesca Demichelis,David M. Nanus,Mark A. Rubin +25 more
TL;DR: There was dramatic and enhanced sensitivity of NEPC (and MYCN overexpressing PCA) to Aurora kinase inhibitor therapy both in vitro and in vivo, with complete suppression of neuroendocrine marker expression following treatment.
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
Christopher E. Barbieri,Sylvan C. Baca,Sylvan C. Baca,Michael S. Lawrence,Francesca Demichelis,Francesca Demichelis,Mirjam Blattner,Jean Philippe Theurillat,Thomas A. White,Petar Stojanov,Eliezer M. Van Allen,Eliezer M. Van Allen,Nicolas Stransky,Elizabeth Nickerson,Sung Suk Chae,Gunther Boysen,Daniel Auclair,Robert C. Onofrio,Kyung Park,Naoki Kitabayashi,Theresa Y. MacDonald,Karen Sheikh,Terry Vuong,Candace Guiducci,Kristian Cibulskis,Andrey Sivachenko,Scott L. Carter,Gordon Saksena,Douglas Voet,Wasay M. Hussain,Alex H. Ramos,Alex H. Ramos,Wendy Winckler,Michelle C Redman,Kristin Ardlie,Ashutosh K. Tewari,Juan Miguel Mosquera,Niels J. Rupp,Peter J. Wild,Holger Moch,Colm Morrissey,Peter S. Nelson,Peter S. Nelson,Philip W. Kantoff,Stacey Gabriel,Todd R. Golub,Matthew Meyerson,Eric S. Lander,Eric S. Lander,Gad Getz,Mark A. Rubin,Levi A. Garraway +51 more
TL;DR: The National Human Genome Research Institute (U.S.) (Large Scale Sequencing Program Grant U54 HG003067) as discussed by the authors has provided a grant for large scale sequencing.