K
Karim Bouzakri
Researcher at University of Strasbourg
Publications - 53
Citations - 3877
Karim Bouzakri is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 22, co-authored 45 publications receiving 3398 citations. Previous affiliations of Karim Bouzakri include University of Geneva & Karolinska Institutet.
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Journal ArticleDOI
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
Helga Ellingsgaard,Irina Hauselmann,Beat Schuler,Abdella M. Habib,Laurie L. Baggio,Daniel T. Meier,Elisabeth Eppler,Karim Bouzakri,Stephan Wueest,Yannick D. Muller,Ann Maria Kruse Hansen,Manfred Reinecke,Daniel Konrad,Max Gassmann,Frank Reimann,Philippe A. Halban,Jesper Gromada,Daniel J. Drucker,Fiona M. Gribble,Jan A. Ehses,Marc Y. Donath +20 more
TL;DR: Interleukin-6 mediates crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand and suggests that drugs modulating this loop may be useful in type 2 diabetes.
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Tumor Necrosis Factor-α Induces Skeletal Muscle Insulin Resistance in Healthy Human Subjects via Inhibition of Akt Substrate 160 Phosphorylation
Peter Plomgaard,Karim Bouzakri,Rikke Krogh-Madsen,Bettina Mittendorfer,Juleen R. Zierath,Bente Klarlund Pedersen +5 more
TL;DR: It is demonstrated that TNF-alpha infusion in healthy humans induces insulin resistance in skeletal muscle, without effect on endogenous glucose production, as estimated by a combined euglycemic insulin clamp and stable isotope tracer method.
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Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.
M. Böni-Schnetzler,Simone Boller,Sarah Debray,Karim Bouzakri,Daniel T. Meier,Richard Prazak,Julie Kerr-Conte,François Pattou,Jan A. Ehses,Frans Schuit,Marc Y. Donath +10 more
TL;DR: It is concluded that FFA and TLR stimulation induce proinflammatory factors in islets and that IL-1RI engagement results in signal amplification.
Journal ArticleDOI
Signaling Specificity of Interleukin-6 Action on Glucose and Lipid Metabolism in Skeletal Muscle
Lubna Al-Khalili,Karim Bouzakri,Stephan Glund,Fredrik Lönnqvist,Heikki A. Koistinen,Anna Krook +5 more
TL;DR: IL-6 increases glycogen synthesis via a PI3-kinase-dependent mechanism and enhances lipid oxidation via an AMPK- dependent mechanism in skeletal muscle.
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siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle
Karim Bouzakri,Anna Zachrisson,Lubna Al-Khalili,Bei B. Zhang,Heikki A. Koistinen,Anna Krook,Juleen R. Zierath +6 more
TL;DR: SiRNA was utilized to decipher the specific role of predominant insulin receptor substrates and Akt isoforms expressed in human skeletal muscle and revealed specialized roles of insulin signaling cascades to metabolic endpoints.