K
Karin Lanthaler
Researcher at University of Manchester
Publications - 16
Citations - 1051
Karin Lanthaler is an academic researcher from University of Manchester. The author has contributed to research in topics: Proteome & Unfolded protein response. The author has an hindex of 13, co-authored 16 publications receiving 995 citations.
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Journal ArticleDOI
Genomic analysis of the secretion stress response in the enzyme-producing cell factory Aspergillus niger
Thomas Guillemette,Thomas Guillemette,Noël Nicolaas Maria Elisabeth Van Peij,Theo Goosen,Karin Lanthaler,Geoffrey D. Robson,Cees A. M. J. J. van den Hondel,Hein Stam,David B. Archer +8 more
TL;DR: Insight has been gained into the molecular basis of protein secretion and secretion-related stress in an effective protein-secreting fungus, and provides an opportunity to identify target genes for manipulation in strain improvement strategies.
Journal ArticleDOI
Further developments towards a genome-scale metabolic model of yeast
Paul D. Dobson,Kieran Smallbone,Daniel Jameson,Evangelos Simeonidis,Karin Lanthaler,Pınar Pir,Chuan-Zhen Lu,Neil Swainston,Warwick B. Dunn,Paul R. Fisher,Duncan Hull,Marie Brown,Olusegun Oshota,Natalie J. Stanford,Douglas B. Kell,Ross D. King,Stephen G. Oliver,Robert Stevens,Pedro Mendes,Pedro Mendes +19 more
TL;DR: The development of the most complete reconstruction of yeast metabolism to date that is based upon reliable literature evidence and richly annotated according to MIRIAM standards is reported.
Journal ArticleDOI
Global absolute quantification of a proteome: Challenges in the deployment of a QconCAT strategy.
Philip Brownridge,Stephen W. Holman,Simon J. Gaskell,Chris M. Grant,Victoria M. Harman,Simon J. Hubbard,Karin Lanthaler,Craig Lawless,Ronan O’Cualain,Paul F. G. Sims,Rachel H. Watkins,Robert J. Beynon +11 more
TL;DR: The challenge of large‐scale quantification of a proteome is discussed, referring to the programme that aims to define the absolute quantity of at least 4000 proteins in the yeast Saccharomyces cerevisiae, based on the well‐established method of stable isotope dilution.
Journal ArticleDOI
Common features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiae.
Mikko Arvas,Tiina Pakula,Karin Lanthaler,Markku Saloheimo,Mari Valkonen,Tapani Suortti,Geoff D. Robson,Merja Penttilä +7 more
TL;DR: Analysis of the genes induced under secretion stress has revealed novel features in the stress response in T. reesei and in filamentous fungi, demonstrating that in addition to the previously rather well characterised induction of genes for many ER proteins or secretion related proteins also other types of responses exist.
Journal ArticleDOI
Transcriptome Analysis of Recombinant Protein Secretion by Aspergillus nidulans and the Unfolded-Protein Response In Vivo
Andrew H. Sims,Manda E. Gent,Karin Lanthaler,Nigel Dunn-Coleman,Stephen G. Oliver,Geoffrey D. Robson +5 more
TL;DR: The effects of recombinant protein secretion on gene expression levels in Aspergillus nidulans are reported by directly comparing a bovine chymosin-producing strain with its parental wild-type strain in continuous culture by using expressed sequence tag microarrays.