Karin Schornagel

TL;DR: These findings identify CD163 as a macrophage receptor for bacteria and suggest that, during bacterial infection, CD163 on resident tissue macrophages acts as an innate immune sensor and inducer of local inflammation.

TL;DR: It is shown that antibody-mediated killing of tumor cells is limited by a mechanism involving the interaction between tumor cell-expressed CD47 and the inhibitory receptor signal regulatory protein-α (SIRPα) on myeloid cells.

TL;DR: It is demonstrated that neutrophils can exert a mode of destruction of cancer cells, which involves antibody-mediated trogocytosis by neutrophil, which can be further improved by targeting CD47-SIRPα interactions.

TL;DR: The results indicate that emotional stress can rapidly induce altered behavior of AM, which is discussed in view of the important role these cells play in the regulation of the local immune responses in the lungs and the possible contribution to asthma.

TL;DR: It is shown that checkpoint inhibition of CD47–SIRPα interactions further enhances destruction of IgA antibody–opsonized cancer cells by human neutrophils, and concludes that IgA-mediated tumor cell destruction can be further enhanced by CD47-SirPα checkpoint inhibition.