R
Robin van Bruggen
Researcher at University of Amsterdam
Publications - 115
Citations - 6089
Robin van Bruggen is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Medicine & Red blood cell. The author has an hindex of 27, co-authored 94 publications receiving 5052 citations.
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Journal ArticleDOI
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.
Catherine Dostert,Virginie Pétrilli,Robin van Bruggen,Chad Steele,Brooke T. Mossman,Jürg Tschopp +5 more
TL;DR: It is shown that asbestos and silica are sensed by the Nalp3 inflammasome, whose subsequent activation leads to interleukin-1β secretion, and support its role as a major proinflammatory “danger” receptor in particulate matter–related pulmonary diseases.
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Oxidative killing of microbes by neutrophils.
TL;DR: Dysfunction of the phagocyte NADPH oxidase results in chronic granulomatous disease, with life-threatening infections in neutrophils and other phagocytic leukocytes.
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The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria
Babs O. Fabriek,Robin van Bruggen,Dong Mei Deng,Antoon J. M. Ligtenberg,Kamran Nazmi,Karin Schornagel,Rianka P. M. Vloet,Christine D. Dijkstra,Timo K. van den Berg +8 more
TL;DR: These findings identify CD163 as a macrophage receptor for bacteria and suggest that, during bacterial infection, CD163 on resident tissue macrophages acts as an innate immune sensor and inducer of local inflammation.
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CD47 functions as a molecular switch for erythrocyte phagocytosis
TL;DR: Findings reveal a more complex role for CD47-SIRPα interactions in erythrocyte phagocytosis, with CD47 acting as a molecular switch for controlling ery throatcytosis.
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Of macrophages and red blood cells; a complex love story
TL;DR: The role of macrophages in the regulation of RBC production, maintenance and clearance and the interactions between these two cell types during transfer of immune complexes and pathogens from RBC to macrophage are discussed.