K
Karluss Thomas
Researcher at International Life Sciences Institute
Publications - 19
Citations - 3730
Karluss Thomas is an academic researcher from International Life Sciences Institute. The author has contributed to research in topics: QT interval & Context (language use). The author has an hindex of 16, co-authored 18 publications receiving 3452 citations.
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Journal ArticleDOI
Concordance of the toxicity of pharmaceuticals in humans and in animals.
Harry Olson,Graham Betton,Denise Robinson,Karluss Thomas,A.M. Monro,Gerald Kolaja,Patrick D. Lilly,James E. Sanders,Glenn Sipes,William Bracken,Michael A. Dorato,Koen Van Deun,Peter Smith,Bruce Berger,Allen H. Heller +14 more
TL;DR: The survey results support the value of in vivo toxicology studies to predict for many significant HTs associated with pharmaceuticals and have helped to identify HT categories that may benefit from improved methods.
Journal ArticleDOI
Research Strategies for Safety Evaluation of Nanomaterials, Part V: Role of Dissolution in Biological Fate and Effects of Nanoscale Particles
Paul Borm,Frederick C. Klaessig,Timothy D. Landry,Brij M. Moudgil,Jürgen Pauluhn,Karluss Thomas,Remi A Trottier,Stewart P. Wood +7 more
TL;DR: This review, combining aspects of particle toxicology, material science, and analytical chemistry, is intended to provide a useful basis for developing relevant dissolution assay(s) for nanoscale particles.
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A multi-laboratory evaluation of a common in vitro pepsin digestion assay protocol used in assessing the safety of novel proteins
Karluss Thomas,M. Aalbers,Gary A. Bannon,Michael J. Bartels,Rebecca J. Dearman,D. J. Esdaile,T. J. Fu,C. M. Glatt,N. Hadfield,C. Hatzos,Susan L. Hefle,J. R. Heylings,Richard E. Goodman,B. Henry,C. Herouet,Michael P. Holsapple,Gregory S. Ladics,Timothy D. Landry,Sue MacIntosh,Elena A. Rice,Laura Privalle,H. Y. Steiner,Reiko Teshima,R. van Ree,Michael R. Woolhiser,J. Zawodny +25 more
TL;DR: Overall, assay pH did not influence the time to disappearance of the full-length protein or protein fragments, however, results across laboratories were more consistent at pH 1.2 than pH 2.0, demonstrating that this common protocol for evaluating the in vitro digestibility of proteins is reproducible and yields consistent results when performed using the same proteins at different laboratories.
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Research Strategies for Safety Evaluation of Nanomaterials, Part II: Toxicological and Safety Evaluation of Nanomaterials, Current Challenges and Data Needs
Michael P. Holsapple,William H. Farland,Timothy D. Landry,Nancy A. Monteiro-Riviere,Janet M. Carter,Nigel J. Walker,Karluss Thomas +6 more
TL;DR: The unique physicochemical properties associated with nanomaterials are reviewed in the context of the difficulties associated with measuring and characterizing them and are discussed as factors that will impact the development of comprehensive toxicological and safety evaluations.
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Research strategies for safety evaluation of nanomaterials, Part I: evaluating the human health implications of exposure to nanoscale materials.
Karluss Thomas,Philip Sayre +1 more
TL;DR: The human health implications of exposure to nanoscales materials in the context of a toxicological risk evaluation are reviewed, the current scope of U.S. Federal research on nanoscale materials, and selected toxicological studies associated with nanoscALE materials are selected to note emerging research in this area are reviewed.