Karluss Thomas

TL;DR: The survey results support the value of in vivo toxicology studies to predict for many significant HTs associated with pharmaceuticals and have helped to identify HT categories that may benefit from improved methods.

TL;DR: This review, combining aspects of particle toxicology, material science, and analytical chemistry, is intended to provide a useful basis for developing relevant dissolution assay(s) for nanoscale particles.

TL;DR: Overall, assay pH did not influence the time to disappearance of the full-length protein or protein fragments, however, results across laboratories were more consistent at pH 1.2 than pH 2.0, demonstrating that this common protocol for evaluating the in vitro digestibility of proteins is reproducible and yields consistent results when performed using the same proteins at different laboratories.

TL;DR: The unique physicochemical properties associated with nanomaterials are reviewed in the context of the difficulties associated with measuring and characterizing them and are discussed as factors that will impact the development of comprehensive toxicological and safety evaluations.

TL;DR: The human health implications of exposure to nanoscales materials in the context of a toxicological risk evaluation are reviewed, the current scope of U.S. Federal research on nanoscale materials, and selected toxicological studies associated with nanoscALE materials are selected to note emerging research in this area are reviewed.