K
Karthik Viswanathan
Researcher at Massachusetts Institute of Technology
Publications - 38
Citations - 3029
Karthik Viswanathan is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Hemagglutinin (influenza) & Glycan. The author has an hindex of 22, co-authored 38 publications receiving 2823 citations. Previous affiliations of Karthik Viswanathan include Charles Stark Draper Laboratory & University of Massachusetts Medical School.
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Journal ArticleDOI
Contaminated heparin associated with adverse clinical events and activation of the contact system.
Takashi Kei Kishimoto,Karthik Viswanathan,Tanmoy Ganguly,Subbiah Elankumaran,Sean W. Smith,Kevin D. Pelzer,Jonathan C. Lansing,Nammalwar Sriranganathan,Ganlin Zhao,Zoya Galcheva-Gargova,Ali Al-Hakim,Gregory Scott Bailey,Blair A. Fraser,Sucharita Roy,Thomas Rogers-Cotrone,Lucinda F. Buhse,Mark T. Whary,James G. Fox,Moheb Nasr,Gerald J. Dal Pan,Zachary Shriver,Robert Langer,Ganesh Venkataraman,K. Frank Austen,Janet Woodcock,Ram Sasisekharan +25 more
TL;DR: An assay to assess the amidolytic activity of kallikrein can supplement analytic tests to protect the heparin supply chain by screening for OSCS and other highly sulfated polysaccharide contaminants of hepar in that can activate the contact system.
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Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events.
Marco Guerrini,Daniela Beccati,Zachary Shriver,Annamaria Naggi,Karthik Viswanathan,Antonella Bisio,Ishan Capila,Jonathan C. Lansing,Sara Guglieri,Blair A. Fraser,Ali Al-Hakim,Nur Sibel Gunay,Zhenqing Zhang,Luke Robinson,Lucinda F. Buhse,Moheb Nasr,Janet Woodcock,Robert Langer,Ganesh Venkataraman,Robert J. Linhardt,Benito Casu,Giangiacomo Torri,Ram Sasisekharan +22 more
TL;DR: Through detailed structural analysis, the contaminant was found to contain a disaccharide repeat unit of glucuronic acid linked β1→3 to a β-N-acetylgalactosamine, indicative of an allergic-type reaction.
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Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin.
Aarthi Chandrasekaran,Aravind Srinivasan,Rahul Raman,Karthik Viswanathan,S. Raguram,Terrence M. Tumpey,Viswanathan Sasisekharan,Ram Sasisekharan +7 more
TL;DR: An integrated biochemical, analytical and data mining approach demonstrates that HAs from the human-adapted H1N1 and H3N2 viruses, but not H5N1 (bird flu) viruses, specifically bind to long α2-6 sialylated glycans with this topology, which could explain why H 5N1 viruses have not yet gained a foothold in the human population.
Journal ArticleDOI
Quantitative biochemical rationale for differences in transmissibility of 1918 pandemic influenza A viruses
Aravind Srinivasan,Karthik Viswanathan,Rahul Raman,Aarthi Chandrasekaran,S. Raguram,Terrence M. Tumpey,Viswanathan Sasisekharan,Ram Sasisekharan +7 more
TL;DR: The dramatic lower binding affinity of NY18 to long α2-6 glycans, as against a mixedα2-3/6 binding, correlates with its inefficient transmission, and this study establishes a quantitative biochemical correlate for influenza A virus transmission.
Journal ArticleDOI
Glycan Receptor Binding of the Influenza A Virus H7N9 Hemagglutinin
Kannan Tharakaraman,Akila Jayaraman,Rahul Raman,Karthik Viswanathan,Nathan W. Stebbins,David Alan Johnson,Zachary Shriver,Viswanathan Sasisekharan,Ram Sasisekharan +8 more
TL;DR: It is reported that the H7N9 HA shows limited binding to human receptors; however, should a single amino acid mutation occur, this would result in structural changes within the receptor binding site that allow for extensive binding tohuman receptors present in the upper respiratory tract.