R
Ravi K. Bhamidipati
Researcher at Monash University
Publications - 5
Citations - 427
Ravi K. Bhamidipati is an academic researcher from Monash University. The author has contributed to research in topics: Hydrophilic interaction chromatography & Selected ion monitoring. The author has an hindex of 5, co-authored 5 publications receiving 376 citations. Previous affiliations of Ravi K. Bhamidipati include Monash University, Parkville campus.
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Journal ArticleDOI
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential
Jose M. Coteron,Maria L. Marco,Jorge Esquivias,Xiaoyi Deng,Karen L. White,John H. White,Maria Koltun,Farah El Mazouni,Sreekanth Kokkonda,Kasiram Katneni,Ravi K. Bhamidipati,David M. Shackleford,Iñigo Angulo-Barturen,Santiago Ferrer,María Belén Jiménez-Díaz,Francisco-Javier Gamo,Elizabeth J. Goldsmith,William N. Charman,Ian Bathurst,David M. Floyd,David Matthews,Jeremy N. Burrows,Pradipsinh K. Rathod,Susan A. Charman,Margaret A. Phillips +24 more
TL;DR: These studies have identified the first candidate in the triazolopyrimidine series to meet previously established progression criteria for efficacy and ADME properties, justifying further development of this compound toward clinical candidate status.
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3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential
Yassir Younis,Frederic Douelle,Tzu-Shean Feng,Diego Gonzàlez Cabrera,Claire Le Manach,Aloysius T. Nchinda,Sandra Duffy,Karen L. White,David M. Shackleford,Julia Morizzi,Janne Mannila,Kasiram Katneni,Ravi K. Bhamidipati,Mohammed K Zabiulla,Jayan T. Joseph,Sridevi Bashyam,David Waterson,Michael J Witty,David J. Hardick,Sergio Wittlin,Sergio Wittlin,Vicky M. Avery,Susan A. Charman,Kelly Chibale +23 more
TL;DR: A novel class of orally active antimalarial 3,5-diaryl-2-aminopyridines has been identified from phenotypic whole cell high-throughput screening of a commercially available SoftFocus kinase library and has good oral bioavailability and a reasonable half-life.
Journal ArticleDOI
Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A2A Receptor Antagonists and Their Biological Evaluation
Sujay Basu,Dinesh A. Barawkar,Sachin Thorat,Yogesh D. Shejul,Meena Patel,Minakshi Naykodi,Vaibhav Jain,Yogesh Salve,Vandna Prasad,Sumit Chaudhary,Indraneel Ghosh,Ganesh Bhat,Azfar Quraishi,Harish Patil,Shariq S. Ansari,Suraj Menon,Vishal Unadkat,Rhishikesh Thakare,Madhav S. Seervi,Ashwinkumar V. Meru,Siddhartha De,Ravi K. Bhamidipati,Sreekanth R. Rouduri,Venkata P. Palle,Anita Chug,Kasim A. Mookhtiar +25 more
TL;DR: Optimization using structure-based drug design approach resulted in discovery of potent and selective adenosine A2A receptor antagonists bearing substituted 1-methylcyclohexyl-carboxamide groups at position 2 of the benzothiazole scaffold and endowed with better solubility and oral bioavailability.
Journal ArticleDOI
Discovery of Potent and Selective A2A Antagonists with Efficacy in Animal Models of Parkinson’s Disease and Depression
Sujay Basu,Dinesh A. Barawkar,Vidya Ramdas,Minakshi Naykodi,Yogesh D. Shejul,Meena Patel,Sachin Thorat,Anil Panmand,K. Kashinath,Rajesh Bonagiri,Vandna Prasad,Ganesh Bhat,Azfar Quraishi,Sumit Chaudhary,Amol Magdum,Ashwinkumar V. Meru,Indraneel Ghosh,Ravi K. Bhamidipati,Amol A. Raje,Vamsi Madgula,Siddhartha De,Sreekanth R. Rouduri,Venkata P. Palle,Anita Chugh,Narayanan Hariharan,Kasim A. Mookhtiar +25 more
TL;DR: A novel series of [1,2,4]triazolo[5,1-f]purin-2-one derivatives that displays functional antagonism of the A2A receptor with a high degree of selectivity over A1, A2B, and A3 receptors are described.
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Simultaneous determination of OZ277, a synthetic 1,2,4-trioxolane antimalarial, and its polar metabolites in rat plasma using hydrophilic interaction chromatography.
TL;DR: A simple, sensitive and selective hydrophilic interaction liquid chromatography-mass spectroscopy (HILIC/MS) method for simultaneous determination of OZ 277 and its major metabolites in rat plasma was developed and validated and has been successfully used for quantifying OZ277 and its metabolites in plasma following intravenous administration to rats.