K
Katariina Nurmi
Researcher at University of Helsinki
Publications - 20
Citations - 706
Katariina Nurmi is an academic researcher from University of Helsinki. The author has contributed to research in topics: Inflammasome & Proinflammatory cytokine. The author has an hindex of 9, co-authored 16 publications receiving 511 citations. Previous affiliations of Katariina Nurmi include Helsinki University Central Hospital & Spanish National Research Council.
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Journal ArticleDOI
Extracellular acidosis is a novel danger signal alerting innate immunity via the NLRP3 inflammasome
Kristiina Rajamäki,Tommy Nordström,Katariina Nurmi,Karl E.O. Åkerman,Petri T. Kovanen,Katariina Öörni,Kari K. Eklund +6 more
TL;DR: The data suggest that acidic environment represents a novel endogenous danger signal alerting the innate immunity, and may contribute to inflammation in acidosis-associated pathologies such as atherosclerosis and post-ischemic inflammatory responses.
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Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes.
Meri Kaustio,Emma Haapaniemi,Helka Göös,Timo Hautala,Giljun Park,Jaana Syrjänen,Elisabet Einarsdottir,Biswajyoti Sahu,Sanna Kilpinen,Samuli Rounioja,Christopher L. Fogarty,Virpi Glumoff,Petri Kulmala,Petri Kulmala,Shintaro Katayama,Fitsum Tamene,Luca Trotta,Ekaterina Morgunova,Kaarel Krjutškov,Katariina Nurmi,Kari K. Eklund,Anssi Lagerstedt,Merja Helminen,Timi Martelius,Satu Mustjoki,Satu Mustjoki,Jussi Taipale,Janna Saarela,Juha Kere,Juha Kere,Markku Varjosalo,Mikko Seppänen +31 more
TL;DR: The findings broaden the scope of phenotypes caused by mutations in NFKB1 and suggest that a subset of autoinflammatory diseases, such as Behçet disease, can be caused by rare monogenic variants in genes of the NF‐&kgr;B pathway.
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Ethanol inhibits activation of NLRP3 and AIM2 inflammasomes in human macrophages--a novel anti-inflammatory action of alcohol.
Katariina Nurmi,Juhani Virkanen,Kristiina Rajamäki,Katri Niemi,Petri T. Kovanen,Kari K. Eklund,Kari K. Eklund +6 more
TL;DR: Ethanol-induced inhibition of the NLRP3 inflammasome activation in macrophages may represent a biological pathway underlying the protective effect of moderate alcohol consumption on coronary heart disease.
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p38δ MAPK: A Novel Regulator of NLRP3 Inflammasome Activation With Increased Expression in Coronary Atherogenesis.
Kristiina Rajamäki,Mikko I. Mäyränpää,Ana Risco,Jarno Tuimala,Katariina Nurmi,Ana Cuenda,Kari K. Eklund,Katariina Öörni,Petri T. Kovanen +8 more
TL;DR: The p38&dgr; mitogen-activated protein kinase was identified as a novel regulator of NLRP3 inflammasome activation in primary human macrophages, and thus, represents a potential target for modulation of atherosclerotic inflammation.
Journal ArticleDOI
Calpain Activity Is Essential for ATP-Driven Unconventional Vesicle-Mediated Protein Secretion and Inflammasome Activation in Human Macrophages.
Elina Välimäki,Elina Välimäki,Wojciech Cypryk,Juhani Virkanen,Katariina Nurmi,Pauli M. Turunen,Kari K. Eklund,Karl E.O. Åkerman,Tuula A. Nyman,Sampsa Matikainen,Sampsa Matikainen +10 more
TL;DR: It is shown that ATP stimulation activates robust vesicle-mediated unconventional protein secretion, including exosome release and membrane shedding, from human macrophages and shows a pivotal role for calpains in the activation of the inflammatory response during ATP exposure.