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Kate D. Meyer
Researcher at Duke University
Publications - 32
Citations - 6889
Kate D. Meyer is an academic researcher from Duke University. The author has contributed to research in topics: RNA & Medicine. The author has an hindex of 14, co-authored 21 publications receiving 4779 citations. Previous affiliations of Kate D. Meyer include Northwestern University & Max Planck Society.
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Journal ArticleDOI
Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
Kate D. Meyer,Yogesh Saletore,Paul Zumbo,Olivier Elemento,Christopher E. Mason,Samie R. Jaffrey +5 more
TL;DR: A method is presented for transcriptome-wide m(6)A localization, which combines m( 6)A-specific methylated RNA immunoprecipitation with next-generation sequencing (MeRIP-Seq) and reveals insights into the epigenetic regulation of the mammalian transcriptome.
Journal ArticleDOI
5′ UTR m6A Promotes Cap-Independent Translation
Kate D. Meyer,Deepak P. Patil,Jun Zhou,Alexandra Zinoviev,Maxim A. Skabkin,Olivier Elemento,Tatyana V. Pestova,Shu-Bing Qian,Samie R. Jaffrey +8 more
TL;DR: It is shown that mRNAs containing N(6)-methyladenosine (m(6)A) in their 5' UTR can be translated in a cap-independent manner, and that diverse cellular stresses induce a transcriptome-wide redistribution of m( 6)A, resulting in increased numbers of m RNAs with 5'UTR m(6), which bypasses 5' cap-binding proteins to promote translation under stresses.
Journal ArticleDOI
The dynamic epitranscriptome: N6-methyladenosine and gene expression control
Kate D. Meyer,Samie R. Jaffrey +1 more
TL;DR: This work has shown that m6A is present in a large subset of the transcriptome in specific regions of mRNA, which suggests that mRNA may undergo post-transcriptional methylation to regulate its fate and function, which is analogous to methyl modifications in DNA.
Journal ArticleDOI
Rethinking m6A Readers, Writers, and Erasers.
Kate D. Meyer,Samie R. Jaffrey +1 more
TL;DR: In this review, recent advances in m6A research are summarized, and it is highlighted how these new findings have reshaped the understanding of how m 6A is regulated in the transcriptome.
Journal ArticleDOI
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry
Martin E. Hess,Simon Hess,Kate D. Meyer,Linda A W Verhagen,Linda Koch,Hella S. Brönneke,Marcelo O. Dietrich,Sabine D. Jordan,Yogesh Saletore,Olivier Elemento,Bengt F. Belgardt,Thomas Franz,Tamas L Horvath,Ulrich Rüther,Samie R. Jaffrey,Peter Kloppenburg,Jens C. Brüning +16 more
TL;DR: It is demonstrated that inactivation of the Fto gene, encoding a nucleic acid demethylase, impairs dopamine receptor type 2 (D2R) and type 3 (D3R) (collectively, 'D2-like receptor')-dependent control of neuronal activity and behavioral responses.