Peter Liu

TL;DR: It is shown that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation and a key mediator of the host response against Gram-negative bacteria.

TL;DR: The mouse I105N/human I104N mutation, which has been shown to prevent macrophage pyroptosis, attenuated both cell killing by p30 in a 293T transient overexpression system and membrane permeabilization in vitro, suggesting that the mutants are actually hypomorphs, but must be above certain concentration to exhibit activity.

TL;DR: The complex that is described is essential for normal cilia function and acts as a diffusion barrier to maintain the cilia membrane as a compartmentalized signalling organelle.

TL;DR: RNF146, tankyrase, and Axin form a protein complex, and it is demonstrated that RNF146 mediates ubiquitylation of all three proteins to target them for proteasomal degradation.

TL;DR: It is found that Mia3’s contribution to protein secretion is broader than previously realized and its absence impairs collagen deposition and normal development of cartilage and bone.