K
Katelyn T. Byrne
Researcher at University of Pennsylvania
Publications - 37
Citations - 2902
Katelyn T. Byrne is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Tumor microenvironment & Immune system. The author has an hindex of 20, co-authored 29 publications receiving 1844 citations. Previous affiliations of Katelyn T. Byrne include Harvard University & Brigham and Women's Hospital.
Papers
More filters
Journal ArticleDOI
Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy
Jinyang Li,Katelyn T. Byrne,Fangxue Yan,Taiji Yamazoe,Zeyu Chen,Timour Baslan,Lee P. Richman,Jeffrey H. Lin,Yu H. Sun,Andrew J. Rech,David Balli,Ceire A. Hay,Yogev Sela,Allyson J. Merrell,Shannon M. Liudahl,Naomi Gordon,Robert J. Norgard,Salina Yuan,Sixiang Yu,Timothy Chao,Shuai Ye,T.S. Karin Eisinger-Mathason,Robert B. Faryabi,John W. Tobias,Scott W. Lowe,Scott W. Lowe,Lisa M. Coussens,E. John Wherry,Robert H. Vonderheide,Ben Z. Stanger +29 more
TL;DR: A library of congenic tumor cell clones from an autochthonous mouse model of pancreatic adenocarcinoma is established, identifying heterogeneous and multifactorial pathways regulating tumor‐cell‐intrinsic mechanisms that dictate the immune microenvironment and thereby responses to immunotherapy.
Journal ArticleDOI
Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma.
Rafael Winograd,Katelyn T. Byrne,Rebecca A. Evans,Pamela M. Odorizzi,Anders R.L. Meyer,David L. Bajor,Cynthia Clendenin,Ben Z. Stanger,Emma E. Furth,E. John Wherry,Robert H. Vonderheide +10 more
TL;DR: It is suggested that in pancreatic carcinoma, a nonimmunogenic tumor, baseline refractoriness to checkpoint inhibitors can be rescued by the priming of a T-cell response with αCD40/chemotherapy.
Journal ArticleDOI
Immunotherapy and Prevention of Pancreatic Cancer.
TL;DR: This Review article discusses promising immunotherapies currently under investigation in pancreatic cancer and provides a roadmap for the development of prevention vaccines for this and other cancers.
Journal ArticleDOI
Resident memory T cells in the skin mediate durable immunity to melanoma.
Brian T. Malik,Katelyn T. Byrne,Katelyn T. Byrne,Jennifer L. Vella,Peisheng Zhang,Tamer B. Shabaneh,Shannon M. Steinberg,Aleksey K. Molodtsov,Jacob S. Bowers,Christina V. Angeles,Chrystal M. Paulos,Yina H. Huang,Yina H. Huang,Mary Jo Turk,Mary Jo Turk +14 more
TL;DR: It is reported that skin-resident memory T cell responses to melanoma are generated naturally as a result of autoimmune vitiligo, and establishes that CD103-dependent TRM cells play a key role in perpetuating antitumor immunity.
Journal ArticleDOI
CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer.
TL;DR: Using genetically engineered mouse models of pancreatic ductal adenocarcinoma, it is demonstrated that a single dose of agonistic CD40 antibody with chemotherapy rendered PDA susceptible to T cell-dependent destruction and potentiated durable remissions.