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Open AccessJournal ArticleDOI

Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy

Jinyang Li, +29 more
- 17 Jul 2018 - 
- Vol. 49, Iss: 1, pp 178
TLDR
A library of congenic tumor cell clones from an autochthonous mouse model of pancreatic adenocarcinoma is established, identifying heterogeneous and multifactorial pathways regulating tumor‐cell‐intrinsic mechanisms that dictate the immune microenvironment and thereby responses to immunotherapy.
About: 
This article is published in Immunity.The article was published on 2018-07-17 and is currently open access. It has received 453 citations till now. The article focuses on the topics: Tumor microenvironment & Immunotherapy.

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Journal ArticleDOI

Cancer immunoediting and resistance to T cell-based immunotherapy

Jake S. O’Donnell, +5 more
- 01 Mar 2019 - 
TL;DR: How a deeper understanding of the mechanisms underlying the cancer immunoediting process can provide insight into the development of resistance to immunotherapies and the strategies that can be used to overcome such resistance is discussed.
Journal ArticleDOI

Clonal replacement of tumor-specific T cells following PD-1 blockade.

Kathryn E. Yost, +15 more
- 29 Jul 2019 - 
TL;DR: Paired single-cell RNA and T cell receptor sequencing on 79,046 cells from site-matched tumors from patients with basal or squamous cell carcinoma before and after anti-PD-1 therapy demonstrates that pre-existing tumor-specific T cells may have limited reinvigoration capacity, and that the T cell response to checkpoint blockade derives from a distinct repertoire of T cell clones that may have just recently entered the tumor.
Journal ArticleDOI

IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma.

Giulia Biffi, +13 more
- 01 Feb 2019 - 
TL;DR: An IL1-induced signaling cascade that leads to JAK/STAT activation and promotes an inflammatory CAF state is identified, suggesting multiple strategies to target these cells in vivo and illuminating strategies to selectively target CAFs that support tumor growth.
Journal ArticleDOI

Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

Peng Junya, +31 more
- 04 Jul 2019 - 
TL;DR: The transcriptomic atlas provided a valuable resource for deciphering the intra-tumoral heterogeneity in PDAC and uncovered a connection between tumor intrinsic transcriptional state and T cell activation, suggesting potential biomarkers for anticancer treatment such as targeted therapy and immunotherapy.
Journal ArticleDOI

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

Keisuke Yamamoto, +20 more
- 22 Apr 2020 - 
TL;DR: It is shown that, in PDAC, MHC-I molecules are selectively targeted for lysosomal degradation by an autophagy-dependent mechanism that involves theAutophagy cargo receptor NBR1 and leads to improved antigen presentation, enhanced anti-tumour T cell responses and reduced tumour growth in syngeneic host mice.
References
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Journal ArticleDOI

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love, +3 more
- 05 Dec 2014 - 
TL;DR: This work presents DESeq2, a method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates, which enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression.
Journal ArticleDOI

Fast and accurate short read alignment with Burrows–Wheeler transform

Heng Li, +1 more
- 01 Jul 2009 - 
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
Journal ArticleDOI

featureCounts: an efficient general-purpose program for assigning sequence reads to genomic features

Yang Liao, +2 more
- 01 Apr 2014 - 
TL;DR: FeatureCounts as discussed by the authors is a read summarization program suitable for counting reads generated from either RNA or genomic DNA sequencing experiments, which implements highly efficient chromosome hashing and feature blocking techniques.
Journal ArticleDOI

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma.

F. Stephen Hodi, +28 more
- 18 Aug 2010 - 
TL;DR: Ipilimumab, with or without a gp100 peptide vaccine, as compared with gp100 alone, improved overall survival in patients with previously treated metastatic melanoma.
Journal ArticleDOI

Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.

Suzanne L. Topalian, +29 more
- 27 Jun 2012 - 
TL;DR: Anti-PD-1 antibody produced objective responses in approximately one in four to one in five patients with non-small-cell lung cancer, melanoma, or renal-cell cancer; the adverse-event profile does not appear to preclude its use.
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