Katherine E. Harris

TL;DR: A focused investigation of the abundance, chromosomal distribution, and mutation spectra of the four strand-specific homopolymer types (A, T, G, C) ≥8 bp in the genome of Caenorhabditis elegans reveals distinct clusters of homopolymers density in autosome arms that are regions of high recombination in C. elegans.

TL;DR: This work identifies new anti-CD3 antibodies from humanized rats that bind to multiple epitopes and elicit varying levels of T-cell activation, and underpins a next-generation T-BsAb platform in which potent cytotoxicity is uncoupled from high levels of cytokine release, which may lead to a wider therapeutic window in the clinic.

TL;DR: It is shown that two distinct Wnt signaling pathways regulate salivary gland migration, and that both the Wnt4-frizzled pathway and a separate Wnt5-derailed pathway are needed for proper salivARY gland migration.

TL;DR: In this article, a phase II, single-arm, registration trial was conducted for the first time for the PEComa with no approved treatment, and the results showed promising results.

TL;DR: This work presents an innovative platform for the rapid development of diverse sets of human HCAbs that have been selected in vivo and combines antibody repertoire analysis with immunization of transgenic rats, called UniRats, that produce chimeric HCABS with fully human VH domains in response to an antigen challenge.