K
Katherine M. Bruner
Researcher at Johns Hopkins University School of Medicine
Publications - 9
Citations - 1835
Katherine M. Bruner is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 8, co-authored 9 publications receiving 1407 citations. Previous affiliations of Katherine M. Bruner include University of Texas at Austin.
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Journal ArticleDOI
Defective proviruses rapidly accumulate during acute HIV-1 infection.
Katherine M. Bruner,Alexandra J. Murray,Ross A. Pollack,Mary Soliman,Sarah B. Laskey,Adam A. Capoferri,Adam A. Capoferri,Jun Lai,Matthew C. Strain,Steven M. Lada,Rebecca Hoh,Ya Chi Ho,Douglas D. Richman,Douglas D. Richman,Steven G. Deeks,Janet D. Siliciano,Robert F. Siliciano,Robert F. Siliciano +17 more
TL;DR: It is demonstrated that early initiation of ART limits the size of the reservoir but does not profoundly affect the proviral landscape, and hurdles that must be overcome are revealed to successfully analyze future HIV-1 cure strategies.
Journal ArticleDOI
A quantitative approach for measuring the reservoir of latent HIV-1 proviruses
Katherine M. Bruner,Katherine M. Bruner,Zheng Wang,Francesco R. Simonetti,Alexandra M. Bender,Kyungyoon J. Kwon,Srona Sengupta,Emily J. Fray,Subul A. Beg,Annukka A.R. Antar,Katharine M. Jenike,Lynn N. Bertagnolli,Adam A. Capoferri,Joshua T. Kufera,Andrew E. Timmons,Christopher L. Nobles,John R. Gregg,Nikolas Wada,Ya Chi Ho,Ya Chi Ho,Hao Zhang,Joseph B. Margolick,Joel N. Blankson,Steven G. Deeks,Frederic D. Bushman,Janet D. Siliciano,Gregory M. Laird,Robert F. Siliciano,Robert F. Siliciano +28 more
TL;DR: It is shown that the dynamics of cells that carry intact and defective proviruses are different in vitro and in vivo, and these findings have implications for targeting the intact provirus that are a barrier to curing HIV infection.
Journal ArticleDOI
Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics
Nina N. Hosmane,Kyungyoon J. Kwon,Katherine M. Bruner,Adam A. Capoferri,Subul A. Beg,Daniel I. S. Rosenbloom,Brandon F. Keele,Ya Chi Ho,Janet D. Siliciano,Robert F. Siliciano +9 more
TL;DR: It is shown that latently infected cells can proliferate in response to mitogens without producing virus, generating progeny cells that can release infectious virus, suggesting that assays relying on one round of activation underestimate reservoir size.
Journal ArticleDOI
Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape.
Ross A. Pollack,R. Brad Jones,Mihaela Pertea,Katherine M. Bruner,Alyssa R. Martin,Allison S. Thomas,Adam A. Capoferri,Adam A. Capoferri,Subul A. Beg,Subul A. Beg,Szu-Han Huang,Sara Karandish,Haiping Hao,Eitan Halper-Stromberg,Patrick C. Yong,Colin Kovacs,Erika Benko,Robert F. Siliciano,Robert F. Siliciano,Ya Chi Ho +19 more
TL;DR: It is shown that defective proviruses can be transcribed into RNAs that are spliced and translated, and cells with defective major splice donors can be recognized by HIV-1-specific cytotoxic T lymphocytes (CTLs).
Journal ArticleDOI
Towards an HIV-1 cure: measuring the latent reservoir
TL;DR: The advantages and disadvantages of various approaches to measuring the latent reservoir of HIV-1 in resting memory CD4(+) T cells are described.