Y
Ya Chi Ho
Researcher at Yale University
Publications - 47
Citations - 5100
Ya Chi Ho is an academic researcher from Yale University. The author has contributed to research in topics: T cell & Medicine. The author has an hindex of 22, co-authored 41 publications receiving 3885 citations. Previous affiliations of Ya Chi Ho include National Taiwan University & National Cheng Kung University.
Papers
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Journal ArticleDOI
Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure
Ya Chi Ho,Liang Shan,Nina N. Hosmane,Jeffrey C. Wang,Sarah B. Laskey,Daniel I. S. Rosenbloom,Jun Lai,Joel N. Blankson,Janet D. Siliciano,Robert F. Siliciano,Robert F. Siliciano +10 more
TL;DR: The identification of replication-competent noninduced proviruses indicates that the size of the latent reservoir-and, hence, the barrier to cure-may be up to 60-fold greater than previously estimated.
Journal ArticleDOI
SARS-CoV-2: a storm is raging.
Savannah F. Pedersen,Ya Chi Ho +1 more
TL;DR: Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design and the authors found that respiratory distress on admission is associated with unfavorable outcomes.
Journal ArticleDOI
Defective proviruses rapidly accumulate during acute HIV-1 infection.
Katherine M. Bruner,Alexandra J. Murray,Ross A. Pollack,Mary Soliman,Sarah B. Laskey,Adam A. Capoferri,Adam A. Capoferri,Jun Lai,Matthew C. Strain,Steven M. Lada,Rebecca Hoh,Ya Chi Ho,Douglas D. Richman,Douglas D. Richman,Steven G. Deeks,Janet D. Siliciano,Robert F. Siliciano,Robert F. Siliciano +17 more
TL;DR: It is demonstrated that early initiation of ART limits the size of the reservoir but does not profoundly affect the proviral landscape, and hurdles that must be overcome are revealed to successfully analyze future HIV-1 cure strategies.
Journal ArticleDOI
A quantitative approach for measuring the reservoir of latent HIV-1 proviruses
Katherine M. Bruner,Katherine M. Bruner,Zheng Wang,Francesco R. Simonetti,Alexandra M. Bender,Kyungyoon J. Kwon,Srona Sengupta,Emily J. Fray,Subul A. Beg,Annukka A.R. Antar,Katharine M. Jenike,Lynn N. Bertagnolli,Adam A. Capoferri,Joshua T. Kufera,Andrew E. Timmons,Christopher L. Nobles,John R. Gregg,Nikolas Wada,Ya Chi Ho,Ya Chi Ho,Hao Zhang,Joseph B. Margolick,Joel N. Blankson,Steven G. Deeks,Frederic D. Bushman,Janet D. Siliciano,Gregory M. Laird,Robert F. Siliciano,Robert F. Siliciano +28 more
TL;DR: It is shown that the dynamics of cells that carry intact and defective proviruses are different in vitro and in vivo, and these findings have implications for targeting the intact provirus that are a barrier to curing HIV infection.
Journal ArticleDOI
Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics
Nina N. Hosmane,Kyungyoon J. Kwon,Katherine M. Bruner,Adam A. Capoferri,Subul A. Beg,Daniel I. S. Rosenbloom,Brandon F. Keele,Ya Chi Ho,Janet D. Siliciano,Robert F. Siliciano +9 more
TL;DR: It is shown that latently infected cells can proliferate in response to mitogens without producing virus, generating progeny cells that can release infectious virus, suggesting that assays relying on one round of activation underestimate reservoir size.