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Sarah B. Laskey
Researcher at Johns Hopkins University School of Medicine
Publications - 11
Citations - 2135
Sarah B. Laskey is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Viral load & Chronic infection. The author has an hindex of 10, co-authored 11 publications receiving 1841 citations. Previous affiliations of Sarah B. Laskey include Johns Hopkins University.
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Journal ArticleDOI
Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure
Ya Chi Ho,Liang Shan,Nina N. Hosmane,Jeffrey C. Wang,Sarah B. Laskey,Daniel I. S. Rosenbloom,Jun Lai,Joel N. Blankson,Janet D. Siliciano,Robert F. Siliciano,Robert F. Siliciano +10 more
TL;DR: The identification of replication-competent noninduced proviruses indicates that the size of the latent reservoir-and, hence, the barrier to cure-may be up to 60-fold greater than previously estimated.
Journal ArticleDOI
Defective proviruses rapidly accumulate during acute HIV-1 infection.
Katherine M. Bruner,Alexandra J. Murray,Ross A. Pollack,Mary Soliman,Sarah B. Laskey,Adam A. Capoferri,Adam A. Capoferri,Jun Lai,Matthew C. Strain,Steven M. Lada,Rebecca Hoh,Ya Chi Ho,Douglas D. Richman,Douglas D. Richman,Steven G. Deeks,Janet D. Siliciano,Robert F. Siliciano,Robert F. Siliciano +17 more
TL;DR: It is demonstrated that early initiation of ART limits the size of the reservoir but does not profoundly affect the proviral landscape, and hurdles that must be overcome are revealed to successfully analyze future HIV-1 cure strategies.
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Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistance.
S. Alireza Rabi,Gregory M. Laird,Christine M. Durand,Sarah B. Laskey,Liang Shan,Justin R. Bailey,Stanley Chioma,Richard D. Moore,Robert F. Siliciano +8 more
TL;DR: It is found that PIs do not affect virion release from infected cells but block entry, reverse transcription, and post-reverse transcription steps, showing that independent inhibition of multiple distinct steps in the life cycle generates the highly cooperative dose-response curves that make these drugs uniquely effective.
Journal ArticleDOI
A mechanistic theory to explain the efficacy of antiretroviral therapy.
TL;DR: A fundamental theory is proposed to explain the mechanistic basis of cART and why it works so well, including a model to assess and predict the efficacy of antiretroviral drugs alone or in combination.
Journal ArticleDOI
Re-evaluating evolution in the HIV reservoir
Daniel I. S. Rosenbloom,Alison L. Hill,Sarah B. Laskey,Robert F. Siliciano,Robert F. Siliciano +4 more
TL;DR: It is argued that ref. 7 does not provide evidence that ongoing replication is an additional barrier to a cure for treated individuals who consistently maintain low viral loads, and that the decay of labile populations may produce false signals of evolution during treatment, even in the absence of viral replication.