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Daniel I. S. Rosenbloom
Researcher at Columbia University
Publications - 47
Citations - 5145
Daniel I. S. Rosenbloom is an academic researcher from Columbia University. The author has contributed to research in topics: Viral load & Population. The author has an hindex of 21, co-authored 40 publications receiving 4305 citations. Previous affiliations of Daniel I. S. Rosenbloom include Columbia University Medical Center & Harvard University.
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Journal ArticleDOI
Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure
Ya Chi Ho,Liang Shan,Nina N. Hosmane,Jeffrey C. Wang,Sarah B. Laskey,Daniel I. S. Rosenbloom,Jun Lai,Joel N. Blankson,Janet D. Siliciano,Robert F. Siliciano,Robert F. Siliciano +10 more
TL;DR: The identification of replication-competent noninduced proviruses indicates that the size of the latent reservoir-and, hence, the barrier to cure-may be up to 60-fold greater than previously estimated.
Journal ArticleDOI
Clonal evolution of glioblastoma under therapy.
Jiguang Wang,Emanuela Cazzato,Erik Ladewig,Veronique Frattini,Daniel I. S. Rosenbloom,Sakellarios Zairis,Francesco Abate,Zhaoqi Liu,Oliver Elliott,Yong Jae Shin,Jin Ku Lee,In-Hee Lee,Woong-Yang Park,Marica Eoli,Andrew J. Blumberg,Anna Lasorella,Do-Hyun Nam,Do-Hyun Nam,Gaetano Finocchiaro,Antonio Iavarone,Raul Rabadan +20 more
TL;DR: In recurrent GBM with wild-type IDH1, high LTBP4 expression is associated with worse prognosis, highlighting the TGF-β pathway as a potential therapeutic target in GBM.
Journal ArticleDOI
Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
James B. Whitney,Alison L. Hill,Srisowmya Sanisetty,Pablo Penaloza-MacMaster,Jinyan Liu,Mayuri Shetty,Lily Parenteau,Crystal Cabral,Jennifer L. Shields,Stephen Blackmore,Jeffrey Y. Smith,Amanda L. Brinkman,Lauren Peter,Sheeba I. Mathew,Kaitlin M. Smith,Erica N. Borducchi,Daniel I. S. Rosenbloom,Mark G. Lewis,Jillian Hattersley,Bei Li,Joseph Hesselgesser,Romas Geleziunas,Merlin L. Robb,Jerome H. Kim,Nelson L. Michael,Dan H. Barouch +25 more
TL;DR: It is demonstrated that the viral reservoir is seeded rapidly after intrarectal SIV infection of rhesus monkeys, during the ‘eclipse’ phase, and before detectable viraemia, which raises important new challenges for HIV-1 eradication strategies.
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Imitation dynamics of vaccination behaviour on social networks
TL;DR: This work sheds light on how imitation of peers shapes individual vaccination choices in social networks, and integrates an epidemiological process into a simple agent-based model of adaptive learning, which suggests parallels to historical scenarios in which vaccination coverage provided herd immunity for some time, but then rapidly dropped.
Journal ArticleDOI
Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations
Gregory M. Laird,C. Korin Bullen,Daniel I. S. Rosenbloom,Alyssa R. Martin,Alison L. Hill,Christine M. Durand,Janet D. Siliciano,Robert F. Siliciano +7 more
TL;DR: It is shown that protein kinase C agonists in combination with bromodomain inhibitor JQ1 or histone deacetylase inhibitors robustly induce HIV-1 transcription and virus production when directly compared with maximum reactivation by T cell activation.