K
Katherine N. Maloney
Researcher at Point Loma Nazarene University
Publications - 23
Citations - 1355
Katherine N. Maloney is an academic researcher from Point Loma Nazarene University. The author has contributed to research in topics: Depsipeptide & Etamycin. The author has an hindex of 12, co-authored 23 publications receiving 1149 citations. Previous affiliations of Katherine N. Maloney include University of California, San Diego & Scripps Research Institute.
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Journal ArticleDOI
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators
Haley Hieronymus,Justin Lamb,Kenneth N. Ross,Xiao P. Peng,Xiao P. Peng,Cristina C. Clement,Anna Rodina,Maria Nieto,Jinyan Du,Kimberly Stegmaier,Srilakshmi M. Raj,Srilakshmi M. Raj,Katherine N. Maloney,Jon Clardy,William C. Hahn,William C. Hahn,Gabriela Chiosis,Todd R. Golub,Todd R. Golub,Todd R. Golub +19 more
TL;DR: This work identifies new modes of HSP90 modulation through a gene expression-based strategy that is similar to celastrol and gedunin and blocks the ability of androgen receptor (AR) signaling states to be modulated.
Journal ArticleDOI
Bisandrographolide from Andrographis paniculata Activates TRPV4 Channels
TL;DR: Experiments show that BAA activates TRPV4 channels, and the possibility that activation of TRpV4 by BAA could play a role in some of the effects of Andrographis extract described in traditional medicine is discussed.
Journal ArticleDOI
Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses.
Daniel W. Udwary,Erin A. Gontang,Adam C. Jones,Carla S. Jones,Andrew W. Schultz,Jaclyn M. Winter,Jane Y. Yang,Nicholas Beauchemin,Todd L. Capson,Benjamin R. Clark,Eduardo Esquenazi,Alessandra S. Eustáquio,Kelle C. Freel,Lena Gerwick,William H. Gerwick,William H. Gerwick,David Gonzalez,Wei-Ting Liu,Karla L. Malloy,Katherine N. Maloney,Markus Nett,Joshawna K. Nunnery,Kevin Penn,Alejandra Prieto-Davó,Thomas L. Simmons,Sara Weitz,Micheal C. Wilson,Louis S. Tisa,Pieter C. Dorrestein,Pieter C. Dorrestein,Bradley S. Moore,Bradley S. Moore +31 more
TL;DR: Bioinformatic analysis of the genome sequences of Frankia strains ACN14a, CcI3, and EAN1pec revealed an unexpected number of secondary metabolic biosynthesis gene clusters, demonstrating species-specific biosynthetic diversity and presenting a clear roadmap for natural products discovery in the Frankia genus.
Journal ArticleDOI
Lodopyridone, a Structurally Unprecedented Alkaloid from a Marine Actinomycete
Katherine N. Maloney,John B. MacMillan,Christopher A. Kauffman,Paul R. Jensen,Antonio G. DiPasquale,Arnold L. Rheingold,William Fenical +6 more
TL;DR: Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC(50) = 3.6 microM and was defined by X-ray crystallography.
Journal ArticleDOI
Screening Natural Products for Inhibitors of Quinone Reductase-2 Using Ultrafiltration LC−MS
Yongsoo Choi,Katherine Jermihov,Sang Jip Nam,Megan Sturdy,Katherine N. Maloney,Xi Qiu,Lucas R. Chadwick,Matthew Main,Shao-Nong Chen,Andrew D. Mesecar,Norman R. Farnsworth,Guido F. Pauli,William Fenical,John M. Pezzuto,Richard R. Van Breemen +14 more
TL;DR: Ultrafiltration LC-MS was shown to be a useful assay for the discovery of inhibitors of QR-2 in complex matrixes such as extracts of bacteria and botanicals.