K
Kathleen Shah
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 10
Citations - 553
Kathleen Shah is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Immune system & Nippostrongylus brasiliensis. The author has an hindex of 5, co-authored 7 publications receiving 358 citations. Previous affiliations of Kathleen Shah include Francis Crick Institute.
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Journal ArticleDOI
Neuronal regulation of type 2 innate lymphoid cells via neuromedin U
Vânia Cardoso,Julie Chesné,Hélder Ribeiro,Bethania García-Cassani,Tânia Carvalho,Tiffany Bouchery,Kathleen Shah,Nuno L. Barbosa-Morais,Nicola L. Harris,Henrique Veiga-Fernandes +9 more
TL;DR: It is shown that neuromedin U (NMU) in mice is a fast and potent regulator of type 2 innate immunity in the context of a functional neuron–ILC2 unit, and this work reveals that neuron–ilC2 cell units confer immediate tissue protection through coordinated neuroimmune sensory responses.
Journal ArticleDOI
The emerging roles of eosinophils in mucosal homeostasis
TL;DR: A number of key studies over the past decade have placed this restricted view of eosinophil function into question, presenting additional evidence for eOSinophils as critical regulators of various homeostatic processes including immune maintenance, organ development, and tissue regeneration.
Journal ArticleDOI
Hookworms Evade Host Immunity by Secreting a Deoxyribonuclease to Degrade Neutrophil Extracellular Traps.
Tiffany Bouchery,Tiffany Bouchery,Mati Moyat,Mati Moyat,Javier Sotillo,Javier Sotillo,Solomon Silverstein,Beatrice Volpe,Gillian Coakley,Theodora-Dorita Tsourouktsoglou,Luke Becker,Kathleen Shah,Manuel Kulagin,Romain Guiet,Mali Camberis,Alfonso J Schmidt,Arne Seitz,Paul R. Giacomin,Graham Le Gros,Venizelos Papayannopoulos,Alex Loukas,Nicola L. Harris +21 more
TL;DR: Neutrophils depletion or NET inhibition altered larvae behavior and enhanced the number of adult worms following murine infection and a potential conserved mechanism of immune evasion are highlighted.
Journal ArticleDOI
The Study of Host Immune Responses Elicited by the Model Murine Hookworms Nippostrongylus brasiliensis and Heligmosomoides polygyrus
Tiffany Bouchery,Beatrice Volpe,Kathleen Shah,Luc Lebon,Kara J. Filbey,Graham LeGros,Nicola L. Harris +6 more
TL;DR: A complete set of methods by which to investigate the natural progression of infection and the host immunological responses in the lung and intestine of H. brasiliensis and H. polygrus–infected mice are provided.
Posted ContentDOI
Small Intestinal Resident Eosinophils Maintain Gut Homeostasis Following Microbial Colonisation
Kathleen Shah,Kathleen Shah,Aline Ignacio,Bernier-Latmani J,Köller Y,Gillian Coakley,Mati Moyat,Mati Moyat,Hamelin R,Armand F,Nicholas C. Wong,Hena R. Ramay,Carolyn A. Thomson,Regula Burkhard,Antoine Dufour,Petrova T,Petrova T,Nicola L. Harris,Nicola L. Harris,Kathy D. McCoy +19 more
TL;DR: In this article, the authors demonstrate a critical role for eosinophils in facilitating mutualistic interactions between host and microbiota and provide a rationale for the functional significance of their early life recruitment in the small intestine.